{"id":"W2027226224","doi":"10.3389/fnins.2014.00366","title":"Lactate oxidation at the mitochondria: a lactate-malate-aspartate shuttle at work","year":2014,"lang":"en","type":"article","venue":"Frontiers in Neuroscience","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Francis Xavier University","funders":"Universität Innsbruck; Medizinische Universität Innsbruck","keywords":"Biochemistry; Glycolysis; Lactic acid; Lactate dehydrogenase; Compartmentalization (fire protection); Phosphocreatine; Mitochondrion; Chemistry; Cytosol; NAD+ kinase; Metabolism; Biophysics; Biology; Enzyme; Endocrinology; Energy metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002895276,0.000163226,0.000145068,0.0000626696,0.0002063913,0.00003761678,0.0003509967,0.0001139056,0.00003163545],"category_scores_gemma":[0.0003197014,0.0001269967,0.00006577576,0.0003094619,0.0002861345,0.00001066071,0.0002174597,0.0001304928,0.00006538018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000370269,"about_ca_system_score_gemma":0.00002639529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006973367,"about_ca_topic_score_gemma":0.00007950186,"domain_scores_codex":[0.9984221,0.0002326993,0.0002157731,0.0005887332,0.0001705106,0.0003701464],"domain_scores_gemma":[0.9992753,0.00002557683,0.0001084086,0.0004700992,0.00002985041,0.000090721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002550224,0.00002410078,0.0292947,0.000004645853,0.000001875587,0.000004875263,0.00007002008,0.0006739436,0.8593704,0.00002428899,0.1091742,0.001101903],"study_design_scores_gemma":[0.000853613,0.0002784995,0.01733351,0.00001083196,0.00001245312,0.00003547848,0.0000292233,0.001334902,0.1610237,0.0001364865,0.8186329,0.0003183648],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9682258,0.0001622667,0.02021816,0.0009227856,0.006724465,0.0003830804,0.00000796878,0.00002496002,0.003330524],"genre_scores_gemma":[0.9385045,0.0002916956,0.002175535,0.003728641,0.0003361342,0.0001116306,0.00006829312,0.00003724724,0.05474634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7094586,"threshold_uncertainty_score":0.5178775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00912090827459124,"score_gpt":0.2211158047551934,"score_spread":0.2119948964806021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}