{"id":"W2027238333","doi":"10.1016/j.bbrc.2014.08.135","title":"GABA protects pancreatic beta cells against apoptosis by increasing SIRT1 expression and activity","year":2014,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre; St. Michael's Hospital; University of Toronto","funders":"Juvenile Diabetes Research Foundation International","keywords":"Sirtuin 1; NAD+ kinase; Apoptosis; Pancreatic islets; Beta cell; Receptor; Cell biology; Islet; Biology; Sirtuin; Chemistry; Internal medicine; Endocrinology; Downregulation and upregulation; Biochemistry; Insulin; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001541235,0.0005071653,0.0004483511,0.0002764975,0.0001699246,0.0004974576,0.0002699526,0.0003566252,0.002037491],"category_scores_gemma":[0.000178662,0.0001947782,0.0004408634,0.0001950451,0.000316164,0.000287803,0.0003419507,0.001163811,0.0004593024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003071563,"about_ca_system_score_gemma":0.0003318799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009150652,"about_ca_topic_score_gemma":0.0014622,"domain_scores_codex":[0.9999017,0.0000213986,0.00001013563,0.0000186939,0.00001641173,0.0000316938],"domain_scores_gemma":[0.9998735,0.0000138328,0.00004018183,0.00002067304,0.00002332237,0.00002842517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004134018,0.0001094932,0.001309938,0.0003039493,0.0001382209,0.0001174567,0.00005568919,0.00009897608,0.9796005,0.0002212339,0.0004083048,0.01350215],"study_design_scores_gemma":[0.0004495496,0.003131895,0.02196331,0.00007935279,0.0004719199,0.0004776704,0.0003541227,0.0004754937,0.9602423,0.0004439962,0.01187751,0.00003277395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751799,0.01736489,0.002573704,0.0009739868,0.0003342659,0.00001654934,0.000444772,0.0002760437,0.002836076],"genre_scores_gemma":[0.9889206,0.006202438,0.001401451,0.0002907303,0.00006609051,0.00001606891,0.000400773,0.00004304411,0.002658784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002037491,"threshold_uncertainty_score":0.006816089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04526344742373088,"score_gpt":0.3471563818573687,"score_spread":0.3018929344336378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}