{"id":"W2027275070","doi":"10.1038/nm.2056","title":"Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin","year":2009,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":431,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; National Eye Institute; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research","keywords":"Huntingtin; NMDA receptor; Memantine; Neuroprotection; Glutamate receptor; Excitotoxicity; CREB; Biology; Cell biology; Neuroscience; Huntingtin Protein; AMPA receptor; Receptor; Mutant; Genetics; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002340178,0.0002636537,0.0004488576,0.0001523262,0.0002011705,0.00001321816,0.0003614644,0.0001730558,0.00006509582],"category_scores_gemma":[0.006921462,0.0002048367,0.00004846779,0.000569241,0.0005468732,0.0001228273,0.0001272902,0.0006792837,0.000004666877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000261855,"about_ca_system_score_gemma":0.00006220162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001372726,"about_ca_topic_score_gemma":0.000005030932,"domain_scores_codex":[0.9978069,0.0002935103,0.0003220799,0.0006267501,0.000618586,0.0003321785],"domain_scores_gemma":[0.9978353,0.001245937,0.0002503572,0.0003679016,0.00008997868,0.0002105757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001566982,0.00007614112,0.006258064,0.00002671036,0.000007747834,0.000007368169,0.000120793,0.00001031526,0.9897594,0.0002227211,0.00007465743,0.003279425],"study_design_scores_gemma":[0.001059473,0.000910057,0.1992125,0.00009172835,0.00004374306,0.000003489722,0.00002170327,0.0001417634,0.7980227,0.0001985576,0.0001401389,0.000154107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99551,0.0002759886,0.00004741386,0.002853766,0.0004147307,0.0004264188,0.00004193696,0.00006995932,0.0003597194],"genre_scores_gemma":[0.9983952,0.0001226854,0.0001415209,0.001056793,0.000241742,0.000008368919,0.000002851041,0.00001437954,0.00001646521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1929545,"threshold_uncertainty_score":0.8352997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02636686660892221,"score_gpt":0.3159261404185545,"score_spread":0.2895592738096323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}