{"id":"W2027368036","doi":"10.1021/es901915f","title":"Isomer-Specific Biotransformation Rates of a Perfluorooctane Sulfonate (PFOS)-Precursor by Cytochrome P450 Isozymes and Human Liver Microsomes","year":2009,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Per- and polyfluoroalkyl substances research","field":"Environmental Science","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Health Canada; University of Alberta","keywords":"Perfluorooctane; Biotransformation; Chemistry; Microsome; Cytochrome P450; CYP1A2; Biomonitoring; Isozyme; Tandem mass spectrometry; Cytochrome; Chromatography; Toxicokinetics; Structural isomer; Environmental chemistry; Mass spectrometry; Enzyme; Biochemistry; Metabolism; Stereochemistry; Organic chemistry; Sulfonate","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003553896,0.0002661689,0.0002787466,0.0003325811,0.0005352065,0.00005554107,0.0008437847,0.0001839566,0.001551651],"category_scores_gemma":[0.000009803018,0.0002400688,0.00005347639,0.001024691,0.005512003,0.0008740387,0.0002697403,0.0002731612,0.0002429918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003517882,"about_ca_system_score_gemma":0.00001053347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007776016,"about_ca_topic_score_gemma":0.00001811061,"domain_scores_codex":[0.9975203,0.00003607617,0.0003660295,0.0006763955,0.0006651972,0.0007360596],"domain_scores_gemma":[0.9992758,0.00002273585,0.0001268689,0.0004035273,0.000004885168,0.0001661921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001614415,0.0001551103,0.01339179,0.00000375348,0.000003166809,0.000004740213,0.0004006684,0.0000061162,0.8858622,0.0002348999,0.0003063992,0.09961503],"study_design_scores_gemma":[0.0004708481,0.0006625694,0.2305174,0.0000164945,0.000006417094,0.00005144237,0.0004382444,0.000113447,0.7510857,0.0007666543,0.01554406,0.0003267413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987881,0.009249348,0.00007062512,0.000707688,0.00002446878,0.000379502,0.00005985465,0.00006699311,0.001560538],"genre_scores_gemma":[0.9954791,0.003545339,0.0004739112,0.00008238266,0.00001015881,0.00001874319,0.00001572906,0.00001155413,0.0003630836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2171256,"threshold_uncertainty_score":0.999361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007897872076850564,"score_gpt":0.2485572715354934,"score_spread":0.2406593994586429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}