{"id":"W2027368036","doi":"10.1021/es901915f","title":"Isomer-Specific Biotransformation Rates of a Perfluorooctane Sulfonate (PFOS)-Precursor by Cytochrome P450 Isozymes and Human Liver Microsomes","year":2009,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Per- and polyfluoroalkyl substances research","field":"Environmental Science","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Health Canada; University of Alberta","keywords":"Perfluorooctane; Biotransformation; Chemistry; Microsome; Cytochrome P450; CYP1A2; Biomonitoring; Isozyme; Tandem mass spectrometry; Cytochrome; Chromatography; Toxicokinetics; Structural isomer; Environmental chemistry; Mass spectrometry; Enzyme; Biochemistry; Metabolism; Stereochemistry; Organic chemistry; Sulfonate","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002928324,0.0002650357,0.0001337952,0.0002738282,0.0001085573,0.000223273,0.00008563591,0.0002195727,0.0007322863],"category_scores_gemma":[0.0006124157,0.0001636826,0.0002312477,0.0002687167,0.0001402614,0.0001694248,0.0001053462,0.0002417456,0.0002896412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002162474,"about_ca_system_score_gemma":0.000199346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001779111,"about_ca_topic_score_gemma":0.001352164,"domain_scores_codex":[0.9997458,0.00008766229,0.0000186806,0.00007337868,0.00005149941,0.0000230219],"domain_scores_gemma":[0.9998214,0.00005847209,0.00004622745,0.00002088827,0.00003666208,0.00001631933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009586682,0.00006798607,0.01520502,0.00004835789,0.00005975083,0.0001192643,0.0001215754,0.0003096698,0.9732206,0.0001264146,0.00009131232,0.009671353],"study_design_scores_gemma":[0.00002819806,0.001465647,0.05382654,0.00000574557,0.0000898766,0.0007988369,0.00007989233,0.002340686,0.9397859,0.0000963034,0.001470005,0.0000122819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936481,0.001014983,0.004152874,0.00003186095,0.000006861462,0.00003734469,0.0003976049,0.00003607847,0.0006742882],"genre_scores_gemma":[0.9934069,0.0008877639,0.003150887,0.00002289077,0.000008878735,0.00005085053,0.001262005,0.0000118883,0.001197862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001779111,"threshold_uncertainty_score":0.003537595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007897872076850564,"score_gpt":0.2485572715354934,"score_spread":0.2406593994586429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}