{"id":"W2027385673","doi":"10.1038/gt.2009.60","title":"Chitosan–plasmid nanoparticle formulations for IM and SC delivery of recombinant FGF-2 and PDGF-BB or generation of antibodies","year":2009,"lang":"en","type":"article","venue":"Gene Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":false,"ca_institutions":"Polytechnique Montréal","funders":"Canadian Institutes of Health Research","keywords":"Recombinant DNA; Gene delivery; Chitosan; Genetic enhancement; Glucosamine; DNA vaccination; Molecular biology; Growth factor; Biology; Chemistry; Biochemistry; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007269149,0.00009135974,0.0001402823,0.00003401329,0.00006658388,0.000009295568,0.00005273385,0.00006262431,0.000004405624],"category_scores_gemma":[0.00001170852,0.00007254227,0.00004138864,0.00003761082,0.00005332872,0.000008853977,0.00001604783,0.00001692442,1.725898e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001705733,"about_ca_system_score_gemma":0.00003088746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001129629,"about_ca_topic_score_gemma":0.00001883327,"domain_scores_codex":[0.9994583,0.0000185202,0.0001961174,0.0001666211,0.00004742152,0.0001130464],"domain_scores_gemma":[0.9996659,0.00001071139,0.00008425436,0.0001382137,0.00007200008,0.00002890986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003719915,0.00005788108,0.001469773,0.000007428792,0.00003620903,1.726131e-7,0.0001216279,0.00003016577,0.974759,0.00005017459,0.0002052568,0.02289036],"study_design_scores_gemma":[0.0008543269,0.001819839,0.009470176,0.000009906063,0.00001166879,0.000006209597,0.00003089559,0.0006638432,0.9864695,0.0002300406,0.0003412222,0.00009237295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968978,0.002081827,0.0005756725,0.0001237121,0.00007137896,0.0001989121,0.00002131644,0.000003645582,0.0000257431],"genre_scores_gemma":[0.9921803,0.005807883,0.001674209,0.0001371599,0.00006391979,0.000008362469,0.00004998263,0.000006763126,0.00007140035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02279799,"threshold_uncertainty_score":0.2958188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03930853655444874,"score_gpt":0.2868443076090782,"score_spread":0.2475357710546295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}