{"id":"W2027386362","doi":"10.1021/tx050121i","title":"Oxidation of 5-Hydroxypyrimidine Nucleosides to 5-Hydroxyhydantoin and Its α-Hydroxy-ketone Isomer","year":2005,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Cancer Research Society","keywords":"Diastereomer; Chemistry; Isomerization; Deamination; Ketone; Aqueous solution; Radical; Oxidative deamination; Medicinal chemistry; Organic chemistry; Stereochemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007159996,0.0001711071,0.0002772834,0.0001692078,0.00004518518,0.00001279794,0.0003535313,0.0003758818,0.0001150536],"category_scores_gemma":[0.0008628772,0.0001742031,0.00005107932,0.0003282576,0.0002783729,0.00001064641,0.0004884514,0.0003178866,0.00004123139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006942936,"about_ca_system_score_gemma":0.00008700379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000973019,"about_ca_topic_score_gemma":0.00001765641,"domain_scores_codex":[0.9980754,0.00009842025,0.0003806854,0.0005569851,0.0002949344,0.000593636],"domain_scores_gemma":[0.9990698,0.0001057927,0.00005574148,0.0003402028,0.0001475389,0.0002809278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001849253,0.0002104135,0.0004451594,0.00005850509,0.00001717468,0.000005235563,0.00006041119,0.00002017648,0.9938248,0.0001934403,0.001819849,0.003159908],"study_design_scores_gemma":[0.000638732,0.000263012,0.0003040718,0.00003127399,0.000004157949,0.00001905926,0.00004505004,0.0003235019,0.9824723,0.0001891137,0.01554125,0.0001684984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931344,0.0007611946,0.00001521235,0.002693065,0.0000300313,0.0002522923,0.000009521561,0.0000106506,0.003093669],"genre_scores_gemma":[0.9978364,0.0003085224,0.0006601094,0.0002926654,0.0002577685,0.00005587646,0.00003714316,0.00002800222,0.0005235152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0137214,"threshold_uncertainty_score":0.7103794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04261858254279444,"score_gpt":0.3664961036367618,"score_spread":0.3238775210939674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}