{"id":"W2027390173","doi":"10.4161/15384101.2014.991194","title":"Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents","year":2015,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Pyroptosis; Cathepsin; Programmed cell death; Cathepsin B; Lysosome; Biology; Cathepsin L1; Cell biology; Cathepsin D; Cathepsin L; Apoptosis; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000295998,0.000358896,0.0004417331,0.0002659842,0.0001705207,0.000488643,0.0002922121,0.0003656906,0.0008088563],"category_scores_gemma":[0.0002368445,0.0001846555,0.000451816,0.000130913,0.0004087246,0.0003836458,0.0003351373,0.0006019492,0.0002804705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004344238,"about_ca_system_score_gemma":0.0003110331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002651615,"about_ca_topic_score_gemma":0.0004146326,"domain_scores_codex":[0.9996926,0.00004916509,0.00005756473,0.00005787067,0.00005896053,0.0000839121],"domain_scores_gemma":[0.9997612,0.00003310478,0.00009486331,0.00002800114,0.00002687983,0.00005596301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001989046,0.00003099668,0.0001831533,0.00004653419,0.000005284647,0.00003569469,0.0000131039,0.00005678849,0.9984854,0.0001620491,0.00002321595,0.0007589033],"study_design_scores_gemma":[0.00003380562,0.0001669982,0.00317734,0.00000655919,0.00001617709,0.0001907034,0.00002831411,0.0008342671,0.9941326,0.00006504595,0.001342505,0.000005652036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907207,0.003031772,0.004010764,0.0001115829,0.00002924211,0.00005828635,0.0002696129,0.0001023625,0.001665468],"genre_scores_gemma":[0.9945561,0.0009957018,0.002450502,0.00005859587,0.000007753831,0.00006678508,0.000354491,0.00002007257,0.001490029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008088563,"threshold_uncertainty_score":0.003152013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01074696213131153,"score_gpt":0.219047712075577,"score_spread":0.2083007499442655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}