{"id":"W2027409044","doi":"10.1016/j.pupt.2012.01.003","title":"Additive anti-inflammatory effects of beta 2 adrenoceptor agonists or glucocorticosteroid with roflumilast in human peripheral blood mononuclear cells","year":2012,"lang":"en","type":"article","venue":"Pulmonary Pharmacology & Therapeutics","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Gilead Sciences (Canada)","funders":"University of Calgary; Gilead Sciences","keywords":"Roflumilast; Formoterol; Salmeterol; Formoterol Fumarate; Pharmacology; Peripheral blood mononuclear cell; Tumor necrosis factor alpha; Medicine; Agonist; Dexamethasone; Internal medicine; Endocrinology; COPD; Chemistry; Receptor; Corticosteroid; In vitro; Budesonide; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001125047,0.0002686634,0.0002794062,0.0000761956,0.0001067286,0.000009613378,0.0001616032,0.0002096395,0.0001881083],"category_scores_gemma":[0.000001249505,0.0002207233,0.00007852833,0.0001192474,0.0002548791,0.00002301995,0.0000816902,0.0001833391,0.000006593768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003201705,"about_ca_system_score_gemma":0.00006686798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006054752,"about_ca_topic_score_gemma":0.000010199,"domain_scores_codex":[0.9986259,0.0001940134,0.000315454,0.0003030804,0.0001314824,0.0004300162],"domain_scores_gemma":[0.9993674,0.00003656549,0.0001940105,0.0002075461,0.00007478742,0.0001197237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009163273,0.0008220915,0.02399549,0.00007153166,0.0003022012,0.00003517615,0.0002839428,0.00008122971,0.9707959,0.000002713304,0.0001649581,0.0025285],"study_design_scores_gemma":[0.00191721,0.0007652824,0.05776875,0.00002557138,0.0003114107,0.00005615646,0.00009915693,0.00005966408,0.9220341,0.000001969784,0.01669904,0.0002616152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970699,0.001578216,0.00006321208,0.00005804653,0.0005164435,0.0005017967,0.00002231634,0.00002185585,0.000168189],"genre_scores_gemma":[0.997426,0.0005839332,0.0001154269,0.0008556009,0.0003677259,0.00006585069,0.0001039202,0.00005228479,0.0004293068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04876167,"threshold_uncertainty_score":0.9000834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008374167913929056,"score_gpt":0.2509266562997823,"score_spread":0.2425524883858533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}