{"id":"W2027416732","doi":"10.1212/01.wnl.0000296811.19811.db","title":"Genetics of familial amyotrophic lateral sclerosis","year":2008,"lang":"en","type":"review","venue":"Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":277,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Notre-Dame","funders":"","keywords":"Amyotrophic lateral sclerosis; SOD1; Genetics; C9orf72; Disease; Biology; Identification (biology); Genetic epidemiology; Gene; Mutation; Medicine; Trinucleotide repeat expansion; Allele; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0000906963,0.000507728,0.002834593,0.000403203,0.00006329202,0.00000754707,0.0004458965,0.0009895567,0.0003020593],"category_scores_gemma":[0.00008374823,0.0003871415,0.0008073003,0.0004521743,0.0005398375,0.00002697695,0.0003217992,0.001380463,0.0002905548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000596855,"about_ca_system_score_gemma":0.0004817815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009156093,"about_ca_topic_score_gemma":0.000004674721,"domain_scores_codex":[0.9966206,0.000436734,0.0009846747,0.0007071979,0.0005598487,0.0006909713],"domain_scores_gemma":[0.9981773,0.00017743,0.0003381252,0.0008881458,0.0001551478,0.000263826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000339842,0.0002480802,0.0004546789,0.007197563,0.0003566516,0.0006180211,0.00003321859,0.000002540127,0.0002148124,0.00002673863,0.001846469,0.9886614],"study_design_scores_gemma":[0.0008538743,0.002820136,0.008518616,0.001524808,0.0004745371,0.001302047,1.047089e-7,0.00002367144,0.000004585666,0.00001410442,0.9841875,0.0002759945],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02076603,0.977091,0.000002538058,0.0002103396,0.000408053,0.000969642,0.00004995074,0.00006112362,0.0004412921],"genre_scores_gemma":[0.001589634,0.9967523,0.000115171,0.0004155827,0.000583389,0.00007539823,0.00008608884,0.0001344339,0.0002480301],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9883854,"threshold_uncertainty_score":0.999858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1147889839078635,"score_gpt":0.3474581027037291,"score_spread":0.2326691187958656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}