{"id":"W2027422803","doi":"10.1002/1529-0131(200005)43:5<1145::aid-anr25>3.0.co;2-t","title":"Extracellular signal–regulated kinase 1/extracellular signal–regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor κB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells","year":2000,"lang":"en","type":"article","venue":"Arthritis & Rheumatism","topic":"Gout, Hyperuricemia, Uric Acid","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; University of Toronto","funders":"National Heart, Lung, and Blood Institute; National Institute on Aging","keywords":"MAPK/ERK pathway; Kinase; Signal transduction; Molecular biology; Protein kinase A; Activator (genetics); Pseudogout; Cell biology; Chemistry; p38 mitogen-activated protein kinases; Biology; Biochemistry; Receptor; Gout","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004111905,0.001095443,0.00153953,0.0006868624,0.0002600006,0.0002000158,0.0002157665,0.0008019101,0.0006802084],"category_scores_gemma":[0.00007846723,0.001103945,0.0001523134,0.0008665777,0.0004225888,0.001480732,0.00008701588,0.0009503126,0.000005904257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003837324,"about_ca_system_score_gemma":0.0001476887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002493924,"about_ca_topic_score_gemma":0.00003082543,"domain_scores_codex":[0.9940956,0.0006329549,0.001909643,0.001434873,0.0007349438,0.001192034],"domain_scores_gemma":[0.9977598,0.0001658684,0.0007060093,0.0005329117,0.0001582646,0.0006771972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002487741,0.0006509978,0.0009727756,0.0004628826,0.0001470824,0.0002811009,0.008753451,0.001244868,0.9675686,0.00001101936,0.00001385941,0.01740562],"study_design_scores_gemma":[0.01025064,0.000837232,0.005848924,0.007101543,0.0000834329,0.00003360861,0.0009784272,0.02222438,0.9514716,0.0001166746,0.00008274694,0.0009708192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845296,0.009894787,0.000479993,0.0001142909,0.0000607714,0.00450497,0.0001629305,0.0002475349,0.000005126546],"genre_scores_gemma":[0.9977734,0.0008621604,0.0005295021,0.00001707733,0.00002032971,0.0001525396,0.0002245631,0.000243333,0.0001770714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02097951,"threshold_uncertainty_score":0.9991411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01060856534521114,"score_gpt":0.2126913742266276,"score_spread":0.2020828088814165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}