{"id":"W2027422803","doi":"10.1002/1529-0131(200005)43:5<1145::aid-anr25>3.0.co;2-t","title":"Extracellular signal–regulated kinase 1/extracellular signal–regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor κB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells","year":2000,"lang":"en","type":"article","venue":"Arthritis & Rheumatism","topic":"Gout, Hyperuricemia, Uric Acid","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; University of Toronto","funders":"National Heart, Lung, and Blood Institute; National Institute on Aging","keywords":"MAPK/ERK pathway; Kinase; Signal transduction; Molecular biology; Protein kinase A; Activator (genetics); Pseudogout; Cell biology; Chemistry; p38 mitogen-activated protein kinases; Biology; Biochemistry; Receptor; Gout","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001411322,0.0007066511,0.0002944059,0.0002357859,0.0002824617,0.0003014751,0.0001619124,0.0003751096,0.002816108],"category_scores_gemma":[0.0001482442,0.0001946206,0.0004554856,0.000221912,0.0002651623,0.0003431627,0.0003133615,0.0005452865,0.0005778934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002540968,"about_ca_system_score_gemma":0.0003435069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003225054,"about_ca_topic_score_gemma":0.0004672536,"domain_scores_codex":[0.999749,0.0000401461,0.00002065941,0.00003831605,0.00007048563,0.00008149011],"domain_scores_gemma":[0.9999132,0.000009508784,0.00003272926,0.000007414466,0.00001654444,0.00002047989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004802484,0.00008408066,0.0005547001,0.0002259006,0.0000112855,0.0002764504,0.00003706052,0.0001076285,0.994885,0.0001773589,0.0001101573,0.003050196],"study_design_scores_gemma":[0.0002275276,0.001104033,0.05524847,0.00007424661,0.00005917299,0.001974972,0.0002788466,0.003027832,0.9259813,0.000583116,0.01141612,0.00002444819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9710398,0.01512136,0.008437106,0.0004522954,0.0001446768,0.0001708729,0.001071526,0.000142007,0.003420409],"genre_scores_gemma":[0.9832749,0.005815846,0.00506329,0.0001077482,0.00005812873,0.0002108531,0.0008577371,0.00001041578,0.004601094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002816108,"threshold_uncertainty_score":0.009420812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01060856534521114,"score_gpt":0.2126913742266276,"score_spread":0.2020828088814165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}