{"id":"W2027447392","doi":"10.1016/j.bmc.2010.12.010","title":"Design, synthesis, and in vitro characterization of novel hybrid peptidomimetic inhibitors of STAT3 protein","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; National Cancer Institute; Ontario Institute for Cancer Research; National Institutes of Health; Leukemia and Lymphoma Society of Canada; University of Toronto; Leukemia and Lymphoma Society","keywords":"Peptidomimetic; STAT3; Chemistry; STAT protein; Electrophoretic mobility shift assay; In vitro; Signal transduction; Cell biology; Proto-oncogene tyrosine-protein kinase Src; Phosphopeptide; Biochemistry; Phosphorylation; Molecular biology; Transcription factor; Peptide; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002794696,0.0001414402,0.0003638719,0.00008131828,0.00001970498,0.000004109312,0.00006694801,0.00009142587,0.0003104257],"category_scores_gemma":[0.0005499839,0.0001239552,0.0000435912,0.000165984,0.000155712,0.00004636136,0.00002775789,0.0003108193,0.000001264018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002947813,"about_ca_system_score_gemma":0.0001890237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003366123,"about_ca_topic_score_gemma":7.151644e-7,"domain_scores_codex":[0.9989406,0.00001327264,0.000457241,0.0002099655,0.0002307956,0.000148167],"domain_scores_gemma":[0.9992655,0.00008499028,0.0002339644,0.0002073142,0.0001187421,0.00008951328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004038123,0.0002870303,0.0002396412,0.0003916153,0.00002250011,0.000008231025,0.00009703843,9.251289e-8,0.9977168,0.000001740229,0.00001230479,0.0008191634],"study_design_scores_gemma":[0.001065144,0.00008075242,0.001984921,0.0005509104,0.00007096348,0.0001511553,0.00009043282,0.0001841038,0.9956454,0.000004599891,0.00007799859,0.00009361107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982685,0.00004404334,0.0009320453,0.0002561261,0.00007338027,0.0002847046,0.00003578305,0.0000164118,0.00008899382],"genre_scores_gemma":[0.9985855,0.00001333698,0.001073812,0.00002184974,0.0001699115,0.00001960817,0.00003739642,0.00002126852,0.00005734325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002071423,"threshold_uncertainty_score":0.5054747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01478097498077473,"score_gpt":0.2368231453451452,"score_spread":0.2220421703643704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}