{"id":"W2027447392","doi":"10.1016/j.bmc.2010.12.010","title":"Design, synthesis, and in vitro characterization of novel hybrid peptidomimetic inhibitors of STAT3 protein","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; National Cancer Institute; Ontario Institute for Cancer Research; National Institutes of Health; Leukemia and Lymphoma Society of Canada; University of Toronto; Leukemia and Lymphoma Society","keywords":"Peptidomimetic; STAT3; Chemistry; STAT protein; Electrophoretic mobility shift assay; In vitro; Signal transduction; Cell biology; Proto-oncogene tyrosine-protein kinase Src; Phosphopeptide; Biochemistry; Phosphorylation; Molecular biology; Transcription factor; Peptide; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001777299,0.000331753,0.0002870384,0.0001566311,0.0001259201,0.0002672728,0.0003016137,0.0002180041,0.001040813],"category_scores_gemma":[0.0001405719,0.0001514842,0.0002136532,0.0001379849,0.0001223709,0.0001718787,0.0001688927,0.0004403346,0.0002891981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003898318,"about_ca_system_score_gemma":0.0001804959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003807534,"about_ca_topic_score_gemma":0.0008687616,"domain_scores_codex":[0.9999157,0.00001108288,0.000006247529,0.00001367357,0.00002808576,0.00002516182],"domain_scores_gemma":[0.9999425,0.00001028567,0.00001689746,0.000004040596,0.000008435481,0.00001775118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002766225,0.00007493934,0.0001045604,0.00006373347,0.0000165293,0.00007959575,0.00001619806,0.001016739,0.9925485,0.0001845572,0.00009047129,0.005527557],"study_design_scores_gemma":[0.0001538254,0.001156034,0.0008894472,0.000005737474,0.00003834284,0.000338451,0.00001629266,0.003075947,0.9889244,0.0000612521,0.005329337,0.000010907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722303,0.003684455,0.01959173,0.0001378386,0.00008151021,0.0002427178,0.0007197505,0.0001299561,0.003181786],"genre_scores_gemma":[0.976986,0.001898701,0.01587,0.0001096642,0.00002223959,0.0001205823,0.001328648,0.00002353126,0.003640595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001040813,"threshold_uncertainty_score":0.003481865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01478097498077473,"score_gpt":0.2368231453451452,"score_spread":0.2220421703643704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}