{"id":"W2027566808","doi":"10.1515/bc.2006.025","title":"Dual antagonists of the bradykinin B1 and B2 receptors based on a postulated common pharmacophore from existing non-peptide antagonists","year":2006,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research","keywords":"Pharmacophore; Chemistry; Receptor; Bradykinin; Acetamide; Stereochemistry; Peptide; Antagonist; Receptor antagonist; Kinin; Pharmacology; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002386272,0.0003352418,0.0008317608,0.0003741994,0.0001123373,0.0004541494,0.0005516754,0.000368583,0.001632522],"category_scores_gemma":[0.0001434362,0.0001786015,0.0003016787,0.0002684516,0.0002475971,0.0004131341,0.0003197403,0.0005749303,0.000713673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002029272,"about_ca_system_score_gemma":0.0002032066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001545286,"about_ca_topic_score_gemma":0.0003964618,"domain_scores_codex":[0.9998378,0.0000302409,0.00001495675,0.00003053127,0.00005664014,0.00002994382],"domain_scores_gemma":[0.9999501,0.000009005936,0.00001322473,0.000007126463,0.000007319121,0.00001331222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004721748,0.0001223706,0.0003373879,0.0002414553,0.00003287472,0.0002108062,0.00003118131,0.0003046622,0.982461,0.0009492357,0.0002009102,0.01463591],"study_design_scores_gemma":[0.0009982233,0.007249698,0.01303992,0.00007045463,0.0003430495,0.004323196,0.00007296218,0.005242084,0.9163412,0.001384467,0.05085398,0.00008082008],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9478902,0.01862385,0.02131687,0.0007118572,0.00008272896,0.000492837,0.001847983,0.000526001,0.008507704],"genre_scores_gemma":[0.9569778,0.01263126,0.02203522,0.0007137245,0.0001003639,0.0002582017,0.002525236,0.0000418274,0.004716399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001632522,"threshold_uncertainty_score":0.005461276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02139800225808944,"score_gpt":0.2696690275533419,"score_spread":0.2482710252952525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}