{"id":"W2027566808","doi":"10.1515/bc.2006.025","title":"Dual antagonists of the bradykinin B1 and B2 receptors based on a postulated common pharmacophore from existing non-peptide antagonists","year":2006,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research","keywords":"Pharmacophore; Chemistry; Receptor; Bradykinin; Acetamide; Stereochemistry; Peptide; Antagonist; Receptor antagonist; Kinin; Pharmacology; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001450877,0.0002862377,0.0004515179,0.0000203254,0.0001656022,0.00002274471,0.0001420068,0.0002658605,0.000268215],"category_scores_gemma":[0.0001244296,0.0001872401,0.0001661917,0.0001970011,0.0003509088,0.00002270537,0.00008430825,0.0002659163,0.000004344618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005728085,"about_ca_system_score_gemma":0.00007313794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004173476,"about_ca_topic_score_gemma":0.000005542521,"domain_scores_codex":[0.9984752,0.00005162008,0.0004762507,0.0004487153,0.0002478634,0.000300362],"domain_scores_gemma":[0.9989606,0.0002899257,0.0002435163,0.0003131703,0.00006372445,0.0001290945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004162046,0.0002759144,0.3611656,0.00005844826,0.00002914111,0.00003052336,0.00003339607,0.00001222682,0.6356845,0.000009715079,0.001210827,0.001073521],"study_design_scores_gemma":[0.001787241,0.0001517816,0.3962047,0.0002217712,0.00005774822,0.00002667003,0.00003351245,0.001212167,0.5979171,0.00008877244,0.002081573,0.0002169915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959792,0.0004328694,0.000004662085,0.0005567231,0.0001460456,0.0002311469,0.000136862,0.00008133311,0.002431183],"genre_scores_gemma":[0.997949,0.0000269982,0.000227528,0.0003750511,0.0004161834,0.000009107559,0.0005658229,0.00002107369,0.0004092093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0377674,"threshold_uncertainty_score":0.7635431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02139800225808944,"score_gpt":0.2696690275533419,"score_spread":0.2482710252952525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}