{"id":"W2027577263","doi":"10.1038/ng.2928","title":"Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4","year":2014,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":385,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University Health Network; University of British Columbia; BC Cancer Agency","funders":"National Cancer Institute","keywords":"SMARCA4; Biology; Somatic cell; Carcinogenesis; Germline mutation; Cancer research; Germline; Ovary; Ovarian cancer; Mutation; Cancer; Chromatin remodeling; Chromatin; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001089205,0.0001061172,0.000112348,0.00002645203,0.00004388028,0.000007606907,0.0001418374,0.0002155007,0.000002826243],"category_scores_gemma":[0.0000862977,0.00008264387,0.00003887139,0.00009727208,0.00005158003,0.000001113602,0.00009007601,0.0002126005,4.848295e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000155135,"about_ca_system_score_gemma":0.00006469244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002694612,"about_ca_topic_score_gemma":0.00008287937,"domain_scores_codex":[0.999343,0.00005149773,0.0001930847,0.0001889431,0.00009072117,0.0001327144],"domain_scores_gemma":[0.9995118,0.00002493738,0.0000863551,0.0002835074,0.00006209689,0.00003132381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001712052,0.00005131253,0.08826737,0.0001346882,0.000008264732,4.325297e-7,0.0001568307,0.001763896,0.9066001,0.00002734079,0.00009899059,0.002873682],"study_design_scores_gemma":[0.001043642,0.0002046153,0.190635,0.00008137508,0.0000482817,0.00001941228,0.0001265283,0.01879218,0.7871468,0.0006190829,0.00101672,0.0002664043],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960487,0.002676598,0.0003787312,0.00006798335,0.0001372791,0.0001243854,0.000008656858,0.000003234478,0.0005544512],"genre_scores_gemma":[0.9965999,0.00008771352,0.002927842,0.0001617599,0.0001020478,0.000004989993,0.00002824344,0.00001646135,0.0000710381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1194533,"threshold_uncertainty_score":0.3370119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008610111913358025,"score_gpt":0.2330455087614577,"score_spread":0.2244353968480997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}