{"id":"W2027587346","doi":"10.1074/jbc.m413265200","title":"Expression of CD45 Lacking the Catalytic Protein Tyrosine Phosphatase Domain Modulates Lck Phosphorylation and T Cell Activation","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Jurkat cells; Protein tyrosine phosphatase; Phosphorylation; Tyrosine phosphorylation; T-cell receptor; Cell biology; T cell; SH2 domain; Signal transduction; Phosphatase; Tyrosine; Proto-oncogene tyrosine-protein kinase Src; Chemistry; Biology; Molecular biology; Biochemistry; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003929676,0.0001617338,0.0002017194,0.00001440872,0.00007349948,0.00002083646,0.0002270795,0.0001919984,0.00002735072],"category_scores_gemma":[0.0002844668,0.00009990537,0.00008977379,0.00007557823,0.0001618862,0.00001854294,0.0001288298,0.0001808148,7.858849e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002640397,"about_ca_system_score_gemma":0.0000476974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003908202,"about_ca_topic_score_gemma":2.611706e-7,"domain_scores_codex":[0.9989818,0.00004364657,0.0004366238,0.0001967501,0.0001652667,0.0001759163],"domain_scores_gemma":[0.9989403,0.00003791894,0.000585927,0.0002198298,0.0001349818,0.00008104967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003160167,0.00009756319,0.0006931344,0.00004416746,0.00001287816,0.000001714665,0.000019743,0.0001088745,0.9969798,0.00002245384,0.0002934116,0.001410226],"study_design_scores_gemma":[0.0006585135,0.0001862238,0.0008007934,0.00009418823,0.00001203703,0.00002839444,0.00005165464,0.00003245973,0.9959367,0.0003013903,0.001775715,0.0001219649],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856201,0.01303701,0.0007885751,0.0002760662,0.00001718965,0.000166469,0.00002975177,0.000004639112,0.00006022408],"genre_scores_gemma":[0.9968363,0.0002568246,0.002428709,0.00006426797,0.0002614754,0.000007952604,0.00009275925,0.00001041295,0.00004131564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01278019,"threshold_uncertainty_score":0.4074023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01143360349236653,"score_gpt":0.2331071094116827,"score_spread":0.2216735059193162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}