{"id":"W2027610480","doi":"10.1074/jbc.c200695200","title":"A Novel Ubiquitin Fusion System Bypasses the Mitochondria and Generates Biologically Active Smac/DIABLO","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa","funders":"National Cancer Institute; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Cytochrome c; Cell biology; Caspase; Fusion protein; Apoptosis; Biology; Cytosol; Cancer cell; Mitochondrion; Ubiquitin; Transfection; XIAP; Programmed cell death; Biochemistry; Cancer; Gene; Enzyme; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001793439,0.0002943725,0.0001806358,0.0002532645,0.0001858915,0.0002912048,0.0002461026,0.000330814,0.0005957715],"category_scores_gemma":[0.00007776076,0.0001286753,0.0001825794,0.0001709445,0.0002209282,0.0003155855,0.0002196524,0.0005879294,0.0002766117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005090313,"about_ca_system_score_gemma":0.0002733459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003008013,"about_ca_topic_score_gemma":0.000384128,"domain_scores_codex":[0.9999126,0.00001149163,0.000009764472,0.00002137505,0.00002556651,0.00001925022],"domain_scores_gemma":[0.9999423,0.000005164192,0.00001658856,0.00000867266,0.000008284669,0.00001892048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003997742,0.00002766489,0.00009453163,0.0000215653,0.000003536415,0.00006255988,0.000007822591,0.00004789848,0.9972969,0.000634514,0.00007788442,0.001685192],"study_design_scores_gemma":[0.00002364387,0.0002413722,0.0007965197,0.000002859208,0.00001326975,0.00051481,0.000006991867,0.0008945004,0.9896541,0.00007532991,0.007768645,0.000008059203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9543135,0.003070056,0.03732716,0.0004210782,0.0001430157,0.0001199231,0.0008275801,0.0003577824,0.003419935],"genre_scores_gemma":[0.973366,0.001295681,0.01918115,0.0001355808,0.00002440237,0.00007135545,0.001580738,0.00003077465,0.004314423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005957715,"threshold_uncertainty_score":0.003693342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01506040771362105,"score_gpt":0.2265740609561122,"score_spread":0.2115136532424912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}