{"id":"W2027646678","doi":"10.3390/biology3040670","title":"DNA Modifications: Function and Applications in Normal and Disease States","year":2014,"lang":"en","type":"review","venue":"Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Canada Research Chairs; CancerCare Manitoba Foundation; Natural Sciences and Engineering Research Council of Canada; Manitoba Health Research Council; Strong; Health Sciences Centre Foundation","keywords":"Biology; DNA methylation; 5-Methylcytosine; Epigenetics; Epigenetics of physical exercise; RNA-Directed DNA Methylation; Genetics; Epigenomics; Histone; Histone methylation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004657424,0.0009313085,0.001271928,0.002294926,0.0003799646,0.0009381995,0.0009091556,0.001194792,0.003351285],"category_scores_gemma":[0.0006743753,0.0003051784,0.0003964166,0.00252256,0.0008966821,0.001487501,0.0008353326,0.001645208,0.002243979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007106314,"about_ca_system_score_gemma":0.0007966024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009243406,"about_ca_topic_score_gemma":0.001238486,"domain_scores_codex":[0.9997928,0.00003425243,0.00003207913,0.00004726227,0.00007397671,0.00001961993],"domain_scores_gemma":[0.9997841,0.0001002056,0.00002701759,0.00001066867,0.00005403304,0.00002406902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006048679,0.00004376873,0.0002321756,0.01038822,0.00005675324,0.000286443,0.0001101185,0.0003948752,0.003753495,0.007865159,0.02273586,0.9540726],"study_design_scores_gemma":[0.000006320756,0.00004415329,0.0005816283,0.001160662,0.00003410571,0.001296793,0.00005589356,0.00006172874,0.0007090668,0.002952454,0.9930808,0.00001644824],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001252265,0.9977456,0.0002429809,0.0002132634,0.0002650173,0.000004151088,0.00001894149,0.000009594029,0.001375156],"genre_scores_gemma":[0.0008594532,0.9974251,0.0002929038,0.000150803,0.000189662,0.000007146131,0.00003055153,0.000002256002,0.001042212],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003351285,"threshold_uncertainty_score":0.0112111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02263080450780836,"score_gpt":0.3121380831842215,"score_spread":0.2895072786764131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}