{"id":"W2027646678","doi":"10.3390/biology3040670","title":"DNA Modifications: Function and Applications in Normal and Disease States","year":2014,"lang":"en","type":"review","venue":"Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Canada Research Chairs; CancerCare Manitoba Foundation; Natural Sciences and Engineering Research Council of Canada; Manitoba Health Research Council; Strong; Health Sciences Centre Foundation","keywords":"Biology; DNA methylation; 5-Methylcytosine; Epigenetics; Epigenetics of physical exercise; RNA-Directed DNA Methylation; Genetics; Epigenomics; Histone; Histone methylation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001363571,0.0001581546,0.000297848,0.00007982676,0.00004866465,0.00001272621,0.0000648608,0.0002387529,0.000002556821],"category_scores_gemma":[0.00005447366,0.0001343256,0.00004741423,0.00006074116,0.00008832131,0.000001419342,0.00006730189,0.00006853594,0.000003417003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006977899,"about_ca_system_score_gemma":0.00006196606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008790656,"about_ca_topic_score_gemma":0.00001705372,"domain_scores_codex":[0.9991257,0.0001186148,0.0002442171,0.0003662622,0.00002176432,0.0001234216],"domain_scores_gemma":[0.9994961,0.00004032606,0.0001151957,0.0002286969,0.00002466963,0.00009501639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001687556,0.00004620493,0.001878837,0.001640352,0.00004461722,1.426329e-7,0.000006072826,0.000004172463,0.0005544574,0.003218733,0.00005208069,0.9925374],"study_design_scores_gemma":[0.00009881689,0.00006813992,0.001134,0.00007630481,0.00008800724,5.872808e-7,0.00000329278,0.00001385804,0.00001074635,0.001788644,0.9965652,0.0001524382],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001168757,0.9929655,0.005249053,0.00001631694,0.00004165327,0.0004067732,0.00007290886,0.000005583865,0.00007343971],"genre_scores_gemma":[0.003753534,0.9932272,0.00008196728,0.00002309513,0.0001582946,0.0002827049,0.002386865,0.00001566282,0.00007063898],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9965131,"threshold_uncertainty_score":0.5477641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02263080450780836,"score_gpt":0.3121380831842215,"score_spread":0.2895072786764131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}