{"id":"W2027652921","doi":"10.1021/cb500757u","title":"Peptide Library Approach to Uncover Phosphomimetic Inhibitors of the BRCA1 C-Terminal Domain","year":2015,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; Canadian Institutes of Health Research; Concern Foundation","keywords":"Phosphoserine; Phosphopeptide; Peptide; Phosphorylation; Serine; Peptide library; Biochemistry; Biology; Phage display; Peptide sequence; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001839954,0.000166658,0.0002135053,0.00002324447,0.00002611385,0.000009064206,0.0005036967,0.0002936585,0.000014524],"category_scores_gemma":[0.0001758213,0.0001131311,0.0001165999,0.0001337355,0.0001680706,0.000004131863,0.0004589967,0.00009654026,0.00001896382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001054071,"about_ca_system_score_gemma":0.00009419815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009739583,"about_ca_topic_score_gemma":3.868507e-7,"domain_scores_codex":[0.9989113,0.0001154465,0.0002490313,0.0003632253,0.0001000435,0.0002609914],"domain_scores_gemma":[0.999237,0.00002477732,0.00009197574,0.0004628725,0.00003549062,0.0001478604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001507336,0.00006782201,0.001398485,0.000008891426,0.00002498893,5.851142e-7,0.00005100138,0.000002181642,0.9900781,0.000667845,0.006379336,0.001170012],"study_design_scores_gemma":[0.0003358656,0.0001600609,0.00006364834,0.000009084746,0.00001077425,0.00002161902,0.00005202969,9.870228e-7,0.9511446,0.002746792,0.04530598,0.0001485241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925412,0.0003383977,0.0004189377,0.0003581133,0.0001933135,0.000241568,0.00002269797,0.00001193263,0.005873837],"genre_scores_gemma":[0.9924856,0.00001144977,0.005758979,0.0008462938,0.00025861,0.00004098278,0.00005946627,0.00002267562,0.0005159534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03893349,"threshold_uncertainty_score":0.4613352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0119407368511479,"score_gpt":0.2219649268609529,"score_spread":0.210024190009805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}