{"id":"W2027652921","doi":"10.1021/cb500757u","title":"Peptide Library Approach to Uncover Phosphomimetic Inhibitors of the BRCA1 C-Terminal Domain","year":2015,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; Canadian Institutes of Health Research; Concern Foundation","keywords":"Phosphoserine; Phosphopeptide; Peptide; Phosphorylation; Serine; Peptide library; Biochemistry; Biology; Phage display; Peptide sequence; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002150607,0.0005276816,0.0003380324,0.0003591214,0.0001424535,0.0004198486,0.0003768643,0.0003035939,0.001303686],"category_scores_gemma":[0.0001350247,0.0002108925,0.0002262248,0.0002482919,0.0001625106,0.000200826,0.0002782431,0.0005415866,0.0006898291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003538779,"about_ca_system_score_gemma":0.0002285176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002474126,"about_ca_topic_score_gemma":0.0005261495,"domain_scores_codex":[0.9998546,0.00002814404,0.000009960089,0.00002965016,0.00005024837,0.00002734062],"domain_scores_gemma":[0.9999343,0.0000136995,0.00002021843,0.000006126571,0.000009150738,0.00001635305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004864783,0.00006826363,0.00005687453,0.00004447115,0.000009308734,0.00009656451,0.00001540079,0.0004130891,0.9950618,0.0003049922,0.0001019646,0.003778622],"study_design_scores_gemma":[0.00001915921,0.000296073,0.0002208681,0.000002867455,0.0000146554,0.0002290113,0.00000705594,0.001151277,0.9935865,0.00005195988,0.004415413,0.000005074492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8971289,0.004264439,0.08680638,0.0003215107,0.0001148547,0.0005453801,0.001642626,0.0007496427,0.008426318],"genre_scores_gemma":[0.9317622,0.003781095,0.04986773,0.0003107277,0.00003765251,0.0003664862,0.001535016,0.0001409504,0.01219819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001303686,"threshold_uncertainty_score":0.004361212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0119407368511479,"score_gpt":0.2219649268609529,"score_spread":0.210024190009805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}