{"id":"W2027658897","doi":"10.1055/s-2009-1216420","title":"From the Bench to the Bedside: How Natural Products Can Find Their Way","year":2009,"lang":"en","type":"article","venue":"Planta Medica","topic":"Malaria Research and Control","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Drug Abuse; Agricultural Research Service; University of British Columbia; University of Illinois at Urbana-Champaign; National Oceanic and Atmospheric Administration; U.S. Food and Drug Administration; National Science Foundation of Sri Lanka; University of Colombo; U.S. Department of Agriculture; Western Carolina University; International Science Council; Chinese Academy of Sciences; Kurukshetra University; National Center for Complementary and Alternative Medicine; China Academy of Traditional Chinese Medicine; National Institutes of Health; National Center for Research Resources; National Institute of Allergy and Infectious Diseases; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; Hong Kong Polytechnic University; National Science Foundation; Deutsche Krebshilfe; National Natural Science Foundation of China; Tata Trusts; University Grants Commission; Wake Forest University","keywords":"Artemisia annua; Artesunate; Biology; Artemisinin; Thioredoxin; Pharmacology; Biochemistry; Gene; Immunology; Plasmodium falciparum","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005603268,0.000494906,0.0006520088,0.0006213356,0.0004645264,0.003416893,0.0007537445,0.002231824,0.01195785],"category_scores_gemma":[0.004947756,0.0002556552,0.0008860365,0.0003339463,0.001352258,0.002929153,0.001063903,0.002926459,0.002176494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004822713,"about_ca_system_score_gemma":0.001080798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005170817,"about_ca_topic_score_gemma":0.002643803,"domain_scores_codex":[0.997344,0.00192255,0.00007482251,0.0001309684,0.0003998482,0.0001278915],"domain_scores_gemma":[0.9982544,0.001052689,0.000224763,0.0001372313,0.0001279579,0.0002029372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004854942,0.002236139,0.001185966,0.004271419,0.0002707496,0.0002612947,0.0006229227,0.0003054463,0.0104705,0.01344227,0.03952421,0.9225542],"study_design_scores_gemma":[0.006181908,0.03049261,0.008619708,0.007875643,0.0005658257,0.001103011,0.001750691,0.0009376188,0.01076359,0.04025162,0.8912822,0.0001756568],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.08645918,0.5528486,0.02344231,0.2606263,0.01060497,0.002306791,0.0006944094,0.0006071871,0.06241025],"genre_scores_gemma":[0.395,0.3464993,0.08911214,0.1135476,0.006798042,0.002742369,0.0006350658,0.0002796918,0.04538573],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.01195785,"threshold_uncertainty_score":0.040003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01463861791601072,"score_gpt":0.2502106521388713,"score_spread":0.2355720342228606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}