{"id":"W2027687400","doi":"10.1016/j.celrep.2015.01.019","title":"The Mitochondrial Metallochaperone SCO1 Is Required to Sustain Expression of the High-Affinity Copper Transporter CTR1 and Preserve Copper Homeostasis","year":2015,"lang":"en","type":"article","venue":"Cell Reports","topic":"Trace Elements in Health","field":"Nursing","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Cytochrome c oxidase; Transporter; Homeostasis; Cell biology; ATP7A; Menkes disease; Mitochondrion; Proteasome; Biology; Gene; Chemistry; Copper; Biochemistry; Copper metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001088412,0.0002694257,0.0003961322,0.00006276911,0.0003548117,0.00006934677,0.0003141241,0.0001675315,0.00005649269],"category_scores_gemma":[0.0003766693,0.0001640675,0.0001208201,0.0002440816,0.0002170127,0.0002182123,0.0001679267,0.0002768317,0.000004961662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001507579,"about_ca_system_score_gemma":0.0001815674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005030961,"about_ca_topic_score_gemma":0.0002171677,"domain_scores_codex":[0.9967491,0.0003008836,0.0009324343,0.0005696996,0.000892963,0.0005548898],"domain_scores_gemma":[0.9973623,0.0002001678,0.0005191243,0.001331894,0.000260342,0.0003261698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004862655,0.001199716,0.05118383,0.0007876611,0.0001817823,0.000329103,0.03387009,0.000356975,0.3796155,0.0001099573,0.5152081,0.01229467],"study_design_scores_gemma":[0.002000427,0.0006055703,0.01948308,0.0002455101,0.0002273242,0.00006126213,0.00240543,0.00001285077,0.8674617,0.001400462,0.1056176,0.0004787681],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881105,0.001191353,0.00003412739,0.005007658,0.003265287,0.001573545,0.00002893537,0.00005155235,0.0007370752],"genre_scores_gemma":[0.9965981,0.0000330887,0.001249944,0.0004553768,0.0002112504,0.00006506093,0.00001064339,0.00005374595,0.001322754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4878462,"threshold_uncertainty_score":0.669048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02717408344366025,"score_gpt":0.2803437043531578,"score_spread":0.2531696209094975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}