{"id":"W2027697236","doi":"10.1016/s0014-5793(00)02148-7","title":"Identification of Asp197 as the catalytic nucleophile in the family 38 α‐mannosidase from bovine kidney lysosomes","year":2000,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Mannosidase; Chemistry; Glycoside hydrolase; Glycoprotein; Enzyme; Nucleophile; Cleavage (geology); Glycosyl; Biochemistry; Stereochemistry; Catalysis; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004027723,0.0001521511,0.0002314335,0.0001194949,0.00009936866,0.00005285423,0.0004977927,0.00006240483,0.0006198012],"category_scores_gemma":[0.0002847499,0.00009311087,0.0001123723,0.0005348195,0.000232561,0.0001294302,0.000039508,0.0003198751,0.000613792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007885908,"about_ca_system_score_gemma":0.0000875258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002919559,"about_ca_topic_score_gemma":0.00003211393,"domain_scores_codex":[0.9981586,0.0001672786,0.0003929388,0.0002973707,0.0006858401,0.0002979504],"domain_scores_gemma":[0.9987969,0.0001886846,0.00008716691,0.0007878686,0.00004780528,0.0000915766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001202195,0.0009896244,0.02903117,0.0002033035,0.000291135,0.0005528179,0.02007653,0.00008548508,0.6523169,0.0001471084,0.2730028,0.02210086],"study_design_scores_gemma":[0.004902366,0.0003848529,0.9221928,0.0002897077,0.0002423122,0.00007563011,0.004574238,0.00100723,0.02193329,0.0006264322,0.04331042,0.00046077],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9308649,0.0003882888,0.000008604798,0.06580869,0.00006506306,0.0006287347,0.00004973955,0.00002553503,0.002160389],"genre_scores_gemma":[0.9783457,0.00006950201,0.00001311729,0.02062532,0.0001458953,0.0000553701,0.0001450832,0.00002445535,0.000575568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8931616,"threshold_uncertainty_score":0.788926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01533438105647029,"score_gpt":0.2728913150937204,"score_spread":0.2575569340372502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}