{"id":"W2027723241","doi":"10.1371/journal.pone.0004565","title":"The Causal Cascade to Multiple Sclerosis: A Model for MS Pathogenesis","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":206,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Concordance; Multiple sclerosis; Genetic predisposition; Disease; Pathogenesis; Genetics; Allele; Biology; Twin study; Immunology; Medicine; Gene; Heritability; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002715203,0.001017857,0.0009680594,0.00172399,0.001072962,0.002139822,0.00209906,0.00186042,0.01204891],"category_scores_gemma":[0.007374722,0.0005683532,0.001890454,0.0008776552,0.002160718,0.0032803,0.001686971,0.002360786,0.001816691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0020318,"about_ca_system_score_gemma":0.002464877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005737244,"about_ca_topic_score_gemma":0.003339405,"domain_scores_codex":[0.9989294,0.0006184681,0.00004052956,0.0001424259,0.0001586361,0.0001105849],"domain_scores_gemma":[0.9957106,0.003230896,0.0004043217,0.0001061686,0.0003269333,0.0002211833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0001348309,0.0001262425,0.004477405,0.0002915603,0.0001605518,0.0008242578,0.0005912291,0.1504514,0.0008115364,0.8255095,0.005141621,0.01147976],"study_design_scores_gemma":[0.0001533438,0.0001487756,0.0008632838,0.00007633839,0.000117882,0.0009560325,0.0001463258,0.398937,0.00009726005,0.5926775,0.005785548,0.00004075273],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.07785185,0.004828246,0.8378069,0.03845254,0.0006815568,0.0003389492,0.001087704,0.0006270339,0.03832516],"genre_scores_gemma":[0.8209292,0.008276518,0.1170889,0.003023865,0.001184352,0.001440512,0.0006506881,0.0001727696,0.04723323],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01204891,"threshold_uncertainty_score":0.04030758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2147285714270692,"score_gpt":0.3165573186754775,"score_spread":0.1018287472484083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}