{"id":"W2027723241","doi":"10.1371/journal.pone.0004565","title":"The Causal Cascade to Multiple Sclerosis: A Model for MS Pathogenesis","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":206,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Concordance; Multiple sclerosis; Genetic predisposition; Disease; Pathogenesis; Genetics; Allele; Biology; Twin study; Immunology; Medicine; Gene; Heritability; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003948906,0.000188563,0.0003830353,0.00008534464,0.0004386779,0.0000465689,0.000201925,0.0000741389,0.000008339127],"category_scores_gemma":[0.002463729,0.0001282263,0.0001242885,0.0002131898,0.00006490442,0.0000546413,0.00008602726,0.0001564733,0.00005015085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001202614,"about_ca_system_score_gemma":0.00008137293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003900001,"about_ca_topic_score_gemma":0.0001809707,"domain_scores_codex":[0.9979774,0.00003658691,0.0002817179,0.0003620874,0.0007031222,0.0006390667],"domain_scores_gemma":[0.9983845,0.0003989139,0.00004572502,0.0005100409,0.0003471812,0.0003136584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.000858716,0.001611677,0.002165115,0.0001029498,0.0003909012,0.000003123752,0.0009692169,0.0001657482,0.9693558,0.00005912454,0.005652405,0.01866522],"study_design_scores_gemma":[0.005946513,0.00184026,0.3188713,0.00105199,0.000540833,0.000002660508,0.0003360842,0.472089,0.1976333,0.0002073029,0.0009442236,0.0005365534],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748999,0.0008462163,0.002518962,0.01794294,0.00002804619,0.003072382,0.0001389837,0.0001574055,0.0003951654],"genre_scores_gemma":[0.977542,0.0008670203,0.01736012,0.001332385,0.0002969331,0.0008024089,0.00001209243,0.00003497437,0.001751993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7717224,"threshold_uncertainty_score":0.5228917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2147285714270692,"score_gpt":0.3165573186754775,"score_spread":0.1018287472484083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}