{"id":"W2027736455","doi":"10.1016/j.bmcl.2014.06.066","title":"Synthesis and receptor binding in trans-CD ring-fused A-CD estrogens: Comparison with the cis-fused isomers","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Carleton University; University of Ottawa","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Canadian Cancer Society","keywords":"Chemistry; Selectivity; Stereochemistry; Binding affinities; Ring (chemistry); Ligand (biochemistry); Estrogen receptor; Affinities; Binding selectivity; Chemical synthesis; Potency; Cis–trans isomerism; Receptor; In vitro; Biochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001382848,0.0001679338,0.0001687411,0.0001259448,0.0001381786,0.0002349227,0.0002141583,0.0001612093,0.002140467],"category_scores_gemma":[0.0001533077,0.0001115571,0.0001501705,0.000189471,0.0001407027,0.0001690271,0.0001237824,0.0002836488,0.0005332596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002383217,"about_ca_system_score_gemma":0.000217171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008831174,"about_ca_topic_score_gemma":0.001118338,"domain_scores_codex":[0.9999295,0.00001323901,0.000005671899,0.00001882477,0.0000100251,0.00002264054],"domain_scores_gemma":[0.9999394,0.00001530295,0.00001046477,0.00001056914,0.00001061566,0.00001355814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005854433,0.00006325876,0.0001833346,0.00009765376,0.00001356122,0.0001115074,0.00005378197,0.000628831,0.9919653,0.0009896713,0.0001573956,0.005150281],"study_design_scores_gemma":[0.00001896594,0.000298184,0.0002501914,0.000003060913,0.00001174117,0.0001187829,0.0000334647,0.0003830261,0.9937768,0.00005313305,0.005047057,0.0000056515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889345,0.001731567,0.003317004,0.00009715339,0.00003665417,0.00002703696,0.0004020887,0.00004609132,0.00540797],"genre_scores_gemma":[0.9908767,0.001009489,0.002686606,0.00004799029,0.000008084841,0.00001084644,0.0003158202,0.00001421567,0.005030177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002140467,"threshold_uncertainty_score":0.007160544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005885681483505966,"score_gpt":0.2071956769246967,"score_spread":0.2013099954411907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}