{"id":"W2027875735","doi":"10.1055/s-2009-1216431","title":"Improving the Odds of Developing New Drugs from Botanicals: Botanical Review Team's Perspectives","year":2009,"lang":"en","type":"article","venue":"Planta Medica","topic":"Complementary and Alternative Medicine Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Drug Abuse; Agricultural Research Service; University of British Columbia; University of Illinois at Urbana-Champaign; National Oceanic and Atmospheric Administration; U.S. Food and Drug Administration; National Science Foundation of Sri Lanka; University of Colombo; U.S. Department of Agriculture; Western Carolina University; International Science Council; Chinese Academy of Sciences; Kurukshetra University; National Center for Complementary and Alternative Medicine; China Academy of Traditional Chinese Medicine; National Institutes of Health; National Center for Research Resources; National Institute of Allergy and Infectious Diseases; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; Hong Kong Polytechnic University; National Science Foundation; Deutsche Krebshilfe; National Natural Science Foundation of China; Tata Trusts; University Grants Commission; Wake Forest University","keywords":"Clinical trial; Medicine; Traditional medicine; Alternative medicine; Drug; Botanical garden; Clinical efficacy; Drug development; Pharmacology; Biology; Surgery; Internal medicine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01015801,0.000456582,0.001080727,0.001554813,0.0004922117,0.003227182,0.0009773402,0.003518263,0.004141946],"category_scores_gemma":[0.015634,0.0001579381,0.001025905,0.001427709,0.0006327227,0.003128335,0.0007636718,0.003945737,0.001425583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001405022,"about_ca_system_score_gemma":0.004714613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001158942,"about_ca_topic_score_gemma":0.004304913,"domain_scores_codex":[0.9970967,0.00131569,0.0003607986,0.0001919851,0.0008695598,0.0001652827],"domain_scores_gemma":[0.9727156,0.01240655,0.002613609,0.0004129854,0.01029758,0.001553686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006618763,0.0002144484,0.0005928012,0.01006711,0.0002077948,0.0003320877,0.0002758929,0.0002911965,0.002530143,0.01062127,0.258193,0.7160123],"study_design_scores_gemma":[0.0003090289,0.00110482,0.001569023,0.008659487,0.0003769048,0.0005797534,0.0003023667,0.0003007703,0.0009650792,0.005823696,0.9799678,0.00004121218],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.001289441,0.8142048,0.0008114307,0.1692724,0.01030455,0.00005832803,0.0000779781,0.00005160805,0.003929479],"genre_scores_gemma":[0.01200526,0.8989227,0.00304973,0.0579107,0.0215269,0.0001007743,0.00009988823,0.00003470451,0.006349319],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.01015801,"threshold_uncertainty_score":0.05372137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03482727004914606,"score_gpt":0.3329571793252172,"score_spread":0.2981299092760712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}