{"id":"W2027890910","doi":"10.1128/jvi.78.10.5244-5257.2004","title":"CD4<sup>+</sup>T Cells from CD4C/HIV<sup>Nef</sup>Transgenic Mice Show Enhanced Activation In Vivo with Impaired Proliferation In Vitro but Are Dispensable for the Development of a Severe AIDS-Like Organ Disease","year":2004,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Toronto; Ontario Institute for Cancer Research; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Biology; In vivo; Transgene; In vitro; Cell biology; Human immunodeficiency virus (HIV); Genetically modified mouse; Molecular biology; Virology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001497534,0.0008261156,0.0003028729,0.0006875556,0.0001839236,0.0004358179,0.000254138,0.0005074464,0.002060255],"category_scores_gemma":[0.0001317324,0.0002947165,0.0002254002,0.0001789744,0.0004316161,0.0002473538,0.0001940264,0.00119988,0.001086927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002410882,"about_ca_system_score_gemma":0.000158046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003886505,"about_ca_topic_score_gemma":0.0005830014,"domain_scores_codex":[0.9998209,0.00002907134,0.00002583903,0.00004002088,0.00004023846,0.00004389189],"domain_scores_gemma":[0.999589,0.00006385787,0.0001270807,0.000053785,0.00002698574,0.0001393695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008685228,0.00001683713,0.0002726162,0.00002114467,0.000004415529,0.00006136078,0.00001284851,0.00002606334,0.99875,0.00003869637,0.00002501727,0.0006841991],"study_design_scores_gemma":[0.00005140043,0.000389892,0.01264429,0.00001446262,0.00003780489,0.001246119,0.00005284571,0.0006779155,0.982389,0.0001230053,0.002363937,0.000009357312],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993856,0.001070776,0.002175327,0.00009505568,0.00002410284,0.00002570404,0.001036033,0.0001944397,0.001522635],"genre_scores_gemma":[0.9856126,0.0008739636,0.003917495,0.0001088413,0.00003311257,0.00008103267,0.003392712,0.0001779647,0.005802201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002060255,"threshold_uncertainty_score":0.006892264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01124458796636066,"score_gpt":0.2309837288556026,"score_spread":0.2197391408892419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}