{"id":"W2027893306","doi":"10.1139/w06-065","title":"Intranasal immunization with a recombinant truncated FimH adhesin adjuvanted with CpG oligodeoxynucleotides protects mice against uropathogenic<i>Escherichia coli</i>challenge","year":2006,"lang":"en","type":"article","venue":"Canadian Journal of Microbiology","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Instituto Nacional de Tecnología Agropecuaria; Université Paris-Est Créteil Val-de-Marne; Johns Hopkins University","keywords":"Bacterial adhesin; Immunogen; Microbiology; Escherichia coli; Adjuvant; Recombinant DNA; Nasal administration; Biology; CpG Oligodeoxynucleotide; Antibody titer; Antibody; Virology; Immunization; Titer; Immunology; Monoclonal antibody","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002316802,0.0005027662,0.000485753,0.0002793795,0.0001300995,0.0002663831,0.0002568247,0.0005752207,0.0007641493],"category_scores_gemma":[0.0001858345,0.0001794116,0.0002143406,0.00009178631,0.0003008013,0.0002341329,0.0001277482,0.0008103711,0.0001895657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002880569,"about_ca_system_score_gemma":0.0003562637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008673638,"about_ca_topic_score_gemma":0.001512646,"domain_scores_codex":[0.9997808,0.00002983216,0.00001858308,0.00004622954,0.00004634272,0.00007810239],"domain_scores_gemma":[0.9997638,0.0000296318,0.00007694442,0.00002229872,0.00002496591,0.00008238942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002458351,0.000143704,0.0001307509,0.00003374913,0.000005221614,0.00001935076,0.000008989897,0.00005295466,0.9982664,0.00002432858,0.00001987823,0.001048904],"study_design_scores_gemma":[0.00007487886,0.004060567,0.002382866,0.00002111372,0.00003068945,0.00013403,0.00002519347,0.000558348,0.9920368,0.00002761636,0.0006426708,0.000005134683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972915,0.0006208759,0.001321584,0.00008070783,0.00003704523,0.00003529726,0.00009752636,0.00007291714,0.0004423607],"genre_scores_gemma":[0.9944478,0.0006175464,0.002783907,0.00008653046,0.00002226433,0.00004194612,0.0002402732,0.00002552263,0.001734272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008673638,"threshold_uncertainty_score":0.002556384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005546234966126597,"score_gpt":0.1910938389040774,"score_spread":0.1855476039379508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}