{"id":"W2027918264","doi":"10.1128/jvi.03435-14","title":"Immune Screening Identifies Novel T Cell Targets Encoded by Antisense Reading Frames of HIV-1","year":2015,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Université de Montréal; Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; U.S. Public Health Service; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Biology; CTL*; Epitope; Open reading frame; Cytotoxic T cell; Reading frame; ENCODE; Immune system; Human immunodeficiency virus (HIV); Genetics; Virology; Computational biology; Peptide sequence; Gene; Antigen; CD8","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001295263,0.0002651772,0.000238892,0.0002248349,0.0001675524,0.0003314897,0.0001363925,0.0002331425,0.001006766],"category_scores_gemma":[0.0003121896,0.000107153,0.000268953,0.0001139568,0.0001615996,0.0001382636,0.0001233022,0.000305667,0.0002315155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001958419,"about_ca_system_score_gemma":0.0001502588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003017411,"about_ca_topic_score_gemma":0.0007608526,"domain_scores_codex":[0.9999337,0.00001001705,0.000004734045,0.00001967353,0.00001971318,0.00001211808],"domain_scores_gemma":[0.9998717,0.00005266873,0.00003492486,0.00000553965,0.00001549997,0.00001959251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002114361,0.00004739654,0.002363768,0.00004085981,0.000009281903,0.0001419623,0.0000125887,0.001063635,0.9915542,0.0002277871,0.00006354393,0.004263448],"study_design_scores_gemma":[0.00008714997,0.001049397,0.01556164,0.00001320701,0.0001187789,0.0009977857,0.00008836845,0.03065044,0.9488738,0.0006760163,0.001865809,0.00001773767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950653,0.0002323171,0.003902551,0.0000432393,0.00001179332,0.00001671502,0.0001253004,0.00005443658,0.0005483595],"genre_scores_gemma":[0.9934567,0.0001397198,0.005612114,0.00006811173,0.000008477971,0.00001006338,0.0003738386,0.00001200892,0.0003188953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001006766,"threshold_uncertainty_score":0.003367901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02107415598697492,"score_gpt":0.2707029286588093,"score_spread":0.2496287726718344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}