{"id":"W2027919884","doi":"10.1016/j.ymeth.2015.02.021","title":"Comprehensive identification of disulfide bonds using non-specific proteinase K digestion and CID-cleavable crosslinking analysis methodology for Orbitrap LC/ESI-MS/MS data","year":2015,"lang":"en","type":"article","venue":"Methods","topic":"Mass Spectrometry Techniques and Applications","field":"Chemistry","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Victoria; Genome British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Orbitrap; Chemistry; Disulfide bond; Chromatography; Identification (biology); Mass spectrometry; Combinatorial chemistry; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001516292,0.0009993903,0.0005166242,0.001416457,0.001038742,0.0009266642,0.0007734523,0.0005547778,0.001836956],"category_scores_gemma":[0.001425037,0.0003817045,0.0005083469,0.001047803,0.0003459875,0.0009573419,0.0006978768,0.001066468,0.0007364377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006632209,"about_ca_system_score_gemma":0.001669958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006967859,"about_ca_topic_score_gemma":0.002690871,"domain_scores_codex":[0.9991785,0.00007716347,0.00008337793,0.000232239,0.000349783,0.00007893604],"domain_scores_gemma":[0.9992929,0.0001175667,0.0001551767,0.0001218518,0.0002543086,0.0000581675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008397608,0.00003413342,0.000973205,0.0002501231,0.00004998165,0.0001307249,0.00008799502,0.0001353122,0.9836695,0.0005112838,0.0006862064,0.01338766],"study_design_scores_gemma":[0.00001276041,0.0000970469,0.005953788,0.0000330074,0.00005885188,0.0008141131,0.00004399831,0.003060167,0.9764479,0.0005220941,0.01292643,0.00002970979],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.5471583,0.005810787,0.4251431,0.000810143,0.0002674201,0.0008338779,0.008805009,0.004503437,0.006667983],"genre_scores_gemma":[0.4495505,0.005168459,0.5189787,0.0007995685,0.00009518924,0.00069841,0.01703081,0.0009704825,0.006707832],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001836956,"threshold_uncertainty_score":0.00801903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2828567060543892,"score_gpt":0.4637538604516463,"score_spread":0.1808971543972571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}