{"id":"W2027922318","doi":"10.1073/pnas.0708385104","title":"Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":210,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Leptin; Orexigenic; Endocrinology; Internal medicine; Arc (geometry); AMPK; Acetyl-CoA carboxylase; Malonyl-CoA; Chemistry; Hypothalamus; Anorectic; Energy homeostasis; Hypophagia; Fatty acid synthesis; Leptin receptor; Fatty acid synthase; Neuropeptide Y receptor; Fatty acid; Beta oxidation; Protein kinase A; Pyruvate carboxylase; Biology; Biochemistry; Phosphorylation; Metabolism; Lipid metabolism; Neuropeptide; Enzyme; Medicine; Food intake; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001515944,0.0001179118,0.0001500937,0.0002898523,0.0002658875,0.00003849358,0.0009151978,0.00008281806,0.00002108479],"category_scores_gemma":[0.001621259,0.00008366545,0.00008122399,0.001444578,0.0006751391,0.0005528185,0.0002274658,0.0001719303,0.000009352154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004872371,"about_ca_system_score_gemma":0.00003070807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003695297,"about_ca_topic_score_gemma":2.722062e-7,"domain_scores_codex":[0.9975904,0.000007188909,0.0003669872,0.0003634369,0.001423602,0.0002484263],"domain_scores_gemma":[0.9990811,0.0002919995,0.000368413,0.00001256764,0.0001715659,0.00007430496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002105489,0.00004088198,0.003021173,0.00001722621,0.000002128657,7.427971e-9,0.0001856056,0.00009053872,0.9639165,0.03204407,0.0002564304,0.0004043489],"study_design_scores_gemma":[0.0001271595,0.0001009421,0.06011306,0.00005271688,0.000003196308,0.00000694819,0.0001268349,0.0001048649,0.9229373,0.01579377,0.0005435854,0.00008956712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827598,0.00001211729,0.000003206018,0.003684471,0.00002827305,0.0002296577,0.000009745134,0.00002310447,0.01324964],"genre_scores_gemma":[0.9978751,0.000007047321,0.0008174407,0.0009444222,0.00008934264,0.000003901639,3.610629e-8,0.000005487899,0.0002572499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05709188,"threshold_uncertainty_score":0.3411778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05740799159861255,"score_gpt":0.3048962358035153,"score_spread":0.2474882442049027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}