{"id":"W2027937744","doi":"10.1021/ol036460p","title":"<i>S</i>-Linked Ganglioside Analogues for Use in Conjugate Vaccines","year":2004,"lang":"en","type":"article","venue":"Organic Letters","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; University of Alberta","funders":"","keywords":"Chemistry; Conjugate; Ganglioside; Ceramide; Sialic acid; Immunogenicity; Glycosylation; Stereochemistry; Biochemistry; Lactose; Hydrolysis; Antigen; Combinatorial chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001021037,0.0003688743,0.0002222069,0.0001709378,0.0001180156,0.0002272628,0.0003189593,0.0002720226,0.002002929],"category_scores_gemma":[0.0001406642,0.0001173408,0.0002237037,0.0001977648,0.0001704443,0.0002327918,0.0001898741,0.0003807856,0.001093074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002184073,"about_ca_system_score_gemma":0.0002065743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003208466,"about_ca_topic_score_gemma":0.000354388,"domain_scores_codex":[0.9999418,0.00001330653,0.000005271732,0.000007370305,0.00001771337,0.00001451339],"domain_scores_gemma":[0.9999392,0.000005652364,0.00002223313,0.000007762585,0.00001124511,0.00001393897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001360548,0.00001706921,0.00006365613,0.00005776483,0.000004240192,0.00008212097,0.000009705174,0.0002311554,0.9942252,0.0005185727,0.0001376804,0.004516673],"study_design_scores_gemma":[0.00002767506,0.0004520028,0.0003365621,0.000007017935,0.00001412706,0.0002907599,0.000006868938,0.0001868426,0.9922966,0.00009722057,0.006279185,0.000005149348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9537311,0.008397168,0.0207045,0.0003089534,0.000190523,0.0002641268,0.0008482473,0.000386387,0.01516886],"genre_scores_gemma":[0.9722848,0.004998331,0.01594281,0.0001423571,0.00004228318,0.0001153561,0.0008889965,0.00008542097,0.005499546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002002929,"threshold_uncertainty_score":0.006700456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01722776857309431,"score_gpt":0.2586197766260715,"score_spread":0.2413920080529772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}