{"id":"W2027937744","doi":"10.1021/ol036460p","title":"<i>S</i>-Linked Ganglioside Analogues for Use in Conjugate Vaccines","year":2004,"lang":"en","type":"article","venue":"Organic Letters","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Glycomics Centre; University of Alberta","funders":"","keywords":"Chemistry; Conjugate; Ganglioside; Ceramide; Sialic acid; Immunogenicity; Glycosylation; Stereochemistry; Biochemistry; Lactose; Hydrolysis; Antigen; Combinatorial chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001182419,0.0001079524,0.0001037123,0.00007429041,0.00004549377,0.00003925541,0.0001338805,0.00007934919,0.00002483144],"category_scores_gemma":[0.0001613554,0.000103031,0.0000539545,0.0001386695,0.0000293569,0.000008393367,0.00004472836,0.00006948121,0.00002310149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000311911,"about_ca_system_score_gemma":0.00005453127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009076144,"about_ca_topic_score_gemma":0.0007370987,"domain_scores_codex":[0.9992115,0.00002488296,0.0001548188,0.0002614801,0.0000893699,0.0002579362],"domain_scores_gemma":[0.9996152,0.00001414341,0.00003391848,0.0002281635,0.00005066207,0.00005794435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007706324,0.00002869917,0.002458234,0.00001075383,0.00001626139,0.00001089613,0.00002844471,0.00007852548,0.995325,0.00003934704,0.001816131,0.0001106259],"study_design_scores_gemma":[0.002465729,0.00011663,0.007136174,0.00001383329,0.00000589291,0.00001117446,0.0000227787,0.00001895499,0.9820413,0.00008564266,0.007906272,0.0001756435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926168,0.00007505602,0.003367694,0.003492552,0.00006822997,0.000332721,0.0000131477,0.00001449968,0.00001935272],"genre_scores_gemma":[0.994632,0.00003326876,0.001125091,0.003778937,0.0001332812,0.00003527096,0.0001458779,0.00002521537,0.00009105705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01328374,"threshold_uncertainty_score":0.4201482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01722776857309431,"score_gpt":0.2586197766260715,"score_spread":0.2413920080529772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}