{"id":"W2027976018","doi":"10.1002/mds.21306","title":"Proteasome inhibitor model of Parkinson's disease in mice is confounded by neurotoxicity of the ethanol vehicle","year":2007,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont; McGill University","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Parkinson's disease; Dopamine; Ethanol; Neurotoxicity; Proteasome inhibitor; Saline; Pharmacology; Intraperitoneal injection; Endocrinology; Internal medicine; Chemistry; Medicine; Proteasome; Toxicity; Biochemistry; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005493003,0.001539022,0.0008740657,0.00166023,0.0005890816,0.0006598856,0.001001855,0.001320415,0.004200957],"category_scores_gemma":[0.0002209006,0.0006925334,0.0006823257,0.0006205654,0.001061663,0.0007254411,0.0005082389,0.002903698,0.001040131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006535758,"about_ca_system_score_gemma":0.0006741096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007279141,"about_ca_topic_score_gemma":0.002607739,"domain_scores_codex":[0.9991812,0.000156851,0.0001061151,0.0002096051,0.0002027163,0.000143425],"domain_scores_gemma":[0.9994228,0.00007763605,0.0001806183,0.0000943128,0.00004375453,0.0001809563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001524331,0.001096456,0.0004074491,0.000139697,0.0000419326,0.0002280035,0.00008639861,0.0001657524,0.9913608,0.00113236,0.0003761947,0.003440669],"study_design_scores_gemma":[0.0002411004,0.00444209,0.003483202,0.00004904366,0.00006641976,0.0007321949,0.00004751571,0.001656827,0.9820307,0.0004415277,0.006791453,0.00001788178],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9703209,0.002797305,0.01521248,0.0009036973,0.0003685104,0.000538778,0.002565353,0.001013119,0.006279762],"genre_scores_gemma":[0.9341176,0.004216179,0.02896057,0.0003785536,0.0001029939,0.001783478,0.0033226,0.0002764011,0.02684166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004200957,"threshold_uncertainty_score":0.01405364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0130003241870157,"score_gpt":0.2495977467907207,"score_spread":0.236597422603705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}