{"id":"W2028024684","doi":"10.1016/j.ymthe.2006.08.750","title":"673. Threshold of Normal Stem Cells for Successful Correction of Murine β-Thalassemia","year":2006,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"Bone marrow; Thalassemia; Erythropoiesis; Chimera (genetics); Biology; Transplantation; Erythrocyte fragility; Ineffective erythropoiesis; Phenotype; Stem cell; Immunology; Andrology; Molecular biology; Gene; Cell biology; Internal medicine; Medicine; Genetics; Anemia; Hemolysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000830835,0.000111206,0.0002893226,0.00008496374,0.00002217743,0.000002285956,0.00005244748,0.00009960018,0.00009291536],"category_scores_gemma":[0.000002473432,0.00009488879,0.00016292,0.0001329286,0.00005208704,0.00002401488,0.000008609627,0.00007591464,0.000004574435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001684935,"about_ca_system_score_gemma":0.00003639797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006536296,"about_ca_topic_score_gemma":0.000005056773,"domain_scores_codex":[0.9992738,0.0000271409,0.0002674155,0.0001604349,0.0001323923,0.0001387588],"domain_scores_gemma":[0.9994197,0.0000320188,0.0001384508,0.0002215258,0.000156724,0.00003151009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001017711,0.0002370316,0.003434128,0.00007458751,0.00005014228,0.000007275983,0.00003136111,0.000477575,0.9897655,0.0001468324,0.001063553,0.003694249],"study_design_scores_gemma":[0.002455728,0.001209673,0.003924317,0.0000323907,0.00002890281,0.00001162189,0.00003156384,0.0007901213,0.9854092,0.00006900352,0.005959149,0.00007830433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907994,0.0005005751,0.005962645,0.00006489341,0.0005439378,0.0003926477,0.000008722795,0.00002690877,0.001700239],"genre_scores_gemma":[0.9977061,0.00009499642,0.0003232004,0.0002183839,0.0001077179,0.00002215874,0.0000384764,0.00002284274,0.001466083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006906709,"threshold_uncertainty_score":0.3869452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01164543952737593,"score_gpt":0.2478845756274422,"score_spread":0.2362391361000662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}