{"id":"W2028041461","doi":"10.1210/en.2012-1931","title":"Lactating Ctcgrp Nulls Lose Twice the Normal Bone Mineral Content due to Fewer Osteoblasts and More Osteoclasts, Whereas Bone Mass Is Fully Restored After Weaning in Association With Up-Regulation of Wnt Signaling and Other Novel Genes","year":2013,"lang":"en","type":"article","venue":"Endocrinology","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. John’s Health Sciences Centre; Memorial University of Newfoundland","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research","keywords":"Endocrinology; Internal medicine; Osteoblast; Lactation; Osteoclast; Biology; Sclerostin; Weaning; Bone resorption; Bone remodeling; Wnt signaling pathway; Osteocyte; Bone mineral; Osteoporosis; Cell biology; Signal transduction; Medicine; Genetics; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001000074,0.0001636988,0.0002368093,0.00006769534,0.00004686445,0.00002872904,0.00005225938,0.00008836236,0.00002829794],"category_scores_gemma":[0.0000713856,0.0001243734,0.00003244281,0.00006763774,0.0000783862,0.00001814358,0.00008927121,0.00007773781,0.00000205981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000156777,"about_ca_system_score_gemma":0.00002840064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005377893,"about_ca_topic_score_gemma":0.0002075509,"domain_scores_codex":[0.9989294,0.0000824517,0.0002700474,0.0002905104,0.0001288149,0.0002987729],"domain_scores_gemma":[0.9994469,0.00003942156,0.0001727482,0.0001523682,0.000121447,0.00006709569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004017964,0.00003279684,0.1370407,0.00002416,0.00004453969,0.000006059507,0.0005736331,0.00007938621,0.8598807,0.00004516813,0.0001288094,0.001742167],"study_design_scores_gemma":[0.003145567,0.0003727379,0.7936253,0.00007946962,0.00008609868,0.0001179735,0.001579198,0.0002880503,0.1990259,0.00002862113,0.001314963,0.0003361323],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963227,0.002359235,0.0001410286,0.0006955373,0.00006311225,0.0003159369,0.00003222997,0.000006810603,0.00006344783],"genre_scores_gemma":[0.9979181,0.00002542726,0.0008856837,0.0005878283,0.0001058252,0.00005661876,0.00001616825,0.0000207776,0.0003836281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6608548,"threshold_uncertainty_score":0.5071801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01006979469860577,"score_gpt":0.2172621287715178,"score_spread":0.207192334072912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}