{"id":"W2028041461","doi":"10.1210/en.2012-1931","title":"Lactating Ctcgrp Nulls Lose Twice the Normal Bone Mineral Content due to Fewer Osteoblasts and More Osteoclasts, Whereas Bone Mass Is Fully Restored After Weaning in Association With Up-Regulation of Wnt Signaling and Other Novel Genes","year":2013,"lang":"en","type":"article","venue":"Endocrinology","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. John’s Health Sciences Centre; Memorial University of Newfoundland","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research","keywords":"Endocrinology; Internal medicine; Osteoblast; Lactation; Osteoclast; Biology; Sclerostin; Weaning; Bone resorption; Bone remodeling; Wnt signaling pathway; Osteocyte; Bone mineral; Osteoporosis; Cell biology; Signal transduction; Medicine; Genetics; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009552325,0.0005461265,0.0003816063,0.0007121419,0.0002054415,0.0003580545,0.000339095,0.0003969567,0.003521634],"category_scores_gemma":[0.0001369433,0.0002725332,0.0003546703,0.0002982876,0.0005218357,0.0001828637,0.0003755107,0.00114255,0.0008427584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002493732,"about_ca_system_score_gemma":0.000189408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007556303,"about_ca_topic_score_gemma":0.001310005,"domain_scores_codex":[0.9996489,0.00001358846,0.00002845507,0.00009998642,0.0001402678,0.00006873061],"domain_scores_gemma":[0.9995869,0.00004247388,0.0001467155,0.00004602746,0.00002507487,0.0001528869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009082413,0.000007403223,0.0003218254,0.00001689965,0.000003958569,0.00009990197,0.000008837013,0.00001383719,0.9987589,0.0000290192,0.00002305316,0.0006255755],"study_design_scores_gemma":[0.00004315664,0.0002364481,0.05387734,0.00001039614,0.00004705286,0.001762289,0.0001067206,0.0004971931,0.9399779,0.0001168793,0.003309004,0.00001571184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933218,0.0006306694,0.002269244,0.0001193291,0.00003969625,0.00001381121,0.002134456,0.0002949029,0.001176122],"genre_scores_gemma":[0.9827204,0.0005796856,0.002828391,0.00009483872,0.00001901427,0.00007246221,0.003113348,0.0001542432,0.01041775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003521634,"threshold_uncertainty_score":0.01178098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01006979469860577,"score_gpt":0.2172621287715178,"score_spread":0.207192334072912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}