{"id":"W2028060683","doi":"10.1016/j.str.2014.09.015","title":"Activation Route of the Schistosoma mansoni Cathepsin B1 Drug Target: Structural Map with a Glycosaminoglycan Switch","year":2014,"lang":"en","type":"article","venue":"Structure","topic":"Parasites and Host Interactions","field":"Immunology and Microbiology","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Helmholtz-Zentrum für Umweltforschung; Grantová Agentura České Republiky; Ministerstvo Školství, Mládeže a Tělovýchovy; Argonne National Laboratory; Bibliographical Society of Canada","keywords":"Zymogen; Protein precursor; Schistosoma mansoni; Biochemistry; Protease; Endopeptidase; Cathepsin; Complement system; Chemistry; Cathepsin C; Biology; Enzyme; Schistosomiasis; Immunology; Antibody","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007409228,0.0002558329,0.0001252952,0.0001190926,0.0002195513,0.0004481268,0.0002635218,0.000325854,0.002076901],"category_scores_gemma":[0.0001106476,0.0001375818,0.000183793,0.0001001573,0.0002604185,0.0004136721,0.0001915474,0.0005137131,0.0004470938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004071974,"about_ca_system_score_gemma":0.0003041951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005014371,"about_ca_topic_score_gemma":0.0004546991,"domain_scores_codex":[0.9999713,0.000005372002,0.00000135622,0.000007301958,0.000006644692,0.00000809018],"domain_scores_gemma":[0.9999577,0.00000724543,0.00001367945,0.000004159545,0.000005231119,0.00001192842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004589131,0.00005173705,0.0007174184,0.00008334243,0.00001620693,0.0008033583,0.00006706001,0.001814891,0.9737728,0.01438254,0.0005029899,0.007328696],"study_design_scores_gemma":[0.00006997956,0.0009024137,0.007798472,0.00002741555,0.0000451601,0.00158407,0.000154322,0.01380476,0.9532591,0.005675008,0.01664954,0.00002976463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714237,0.002149082,0.01041225,0.0008664911,0.00005063637,0.00005677871,0.0002496736,0.0001202689,0.01467117],"genre_scores_gemma":[0.9926286,0.00102522,0.003147266,0.00009833832,0.00001384927,0.00001789812,0.0001560461,0.00000914319,0.002903545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002076901,"threshold_uncertainty_score":0.006947875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00298708921999395,"score_gpt":0.2080246626805818,"score_spread":0.2050375734605879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}