{"id":"W2028060683","doi":"10.1016/j.str.2014.09.015","title":"Activation Route of the Schistosoma mansoni Cathepsin B1 Drug Target: Structural Map with a Glycosaminoglycan Switch","year":2014,"lang":"en","type":"article","venue":"Structure","topic":"Parasites and Host Interactions","field":"Immunology and Microbiology","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Helmholtz-Zentrum für Umweltforschung; Grantová Agentura České Republiky; Ministerstvo Školství, Mládeže a Tělovýchovy; Argonne National Laboratory; Bibliographical Society of Canada","keywords":"Zymogen; Protein precursor; Schistosoma mansoni; Biochemistry; Protease; Endopeptidase; Cathepsin; Complement system; Chemistry; Cathepsin C; Biology; Enzyme; Schistosomiasis; Immunology; Antibody","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003398526,0.0001833139,0.0002121054,0.00005569668,0.0002803282,0.00001436001,0.0002773532,0.0001177938,0.0004550139],"category_scores_gemma":[0.00002337953,0.0001075063,0.00008130407,0.000120638,0.0001775477,0.0001045562,0.00004597901,0.0003926148,0.00001901623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004891219,"about_ca_system_score_gemma":0.00005662738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006326065,"about_ca_topic_score_gemma":0.0005702967,"domain_scores_codex":[0.9992026,0.0001041101,0.0001839657,0.0002267614,0.00005310381,0.0002294698],"domain_scores_gemma":[0.9992539,0.00005143271,0.0002105571,0.0003917801,0.00007545364,0.00001689424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003838046,0.00002355398,0.05813023,0.00003895228,0.0002452474,6.508114e-7,0.002371618,0.0001553806,0.9255894,0.007506911,0.00284715,0.002707129],"study_design_scores_gemma":[0.001267534,0.0001388506,0.3186194,0.00008413442,0.00008275764,0.0001416499,0.0003282547,0.00004367469,0.5880551,0.003880695,0.08706149,0.0002964174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969984,0.0001510386,0.0001522649,0.0009032818,0.0008458966,0.000192308,0.0001295727,0.00003219977,0.0005950507],"genre_scores_gemma":[0.9961635,0.000001084774,0.0004122677,0.0001945592,0.00006706251,0.000005260441,0.0001090807,0.00001704072,0.003030121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3375342,"threshold_uncertainty_score":0.4982083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00298708921999395,"score_gpt":0.2080246626805818,"score_spread":0.2050375734605879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}