{"id":"W2028084006","doi":"10.2174/13816128113199990458","title":"Transporter-Based Delivery of Anticancer Drugs to the Brain: Improving Brain Penetration by Minimizing Drug Efflux at the Blood-Brain Barrier","year":2014,"lang":"en","type":"review","venue":"Current Pharmaceutical Design","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Efflux; Blood–brain barrier; Abcg2; Pharmacology; Paracellular transport; P-glycoprotein; Transporter; ATP-binding cassette transporter; Drug; Drug delivery; Medicine; Brain tumor; Drug resistance; Drug delivery to the brain; Central nervous system; Multiple drug resistance; Biology; Chemistry; Permeability (electromagnetism); Internal medicine; Pathology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003242482,0.0009058794,0.002020366,0.0002016062,0.0003497025,0.00006389059,0.0007607315,0.0003021817,0.0005191976],"category_scores_gemma":[0.0002085754,0.0005106966,0.001135634,0.0006266484,0.0003787383,0.00008215989,0.00005371708,0.001202412,0.00006748419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002036674,"about_ca_system_score_gemma":0.000831631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007355242,"about_ca_topic_score_gemma":0.000008347549,"domain_scores_codex":[0.9943939,0.0009712852,0.001519186,0.001012804,0.001216922,0.0008859435],"domain_scores_gemma":[0.9947594,0.003082342,0.0004892587,0.0009042413,0.0001704671,0.0005942213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003739414,0.0003897113,0.00001060824,0.02393252,0.0004164455,0.00001913851,0.0004594,0.00002338421,0.003778718,0.0001222514,0.04487254,0.9256014],"study_design_scores_gemma":[0.00190824,0.0001891674,0.000005777401,0.008732536,0.004878281,0.00001277727,0.00003147386,0.000825735,0.00887936,0.000008471199,0.9739313,0.0005969101],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004425365,0.9438763,0.03988698,0.008679426,0.001280592,0.005320645,0.0003214845,0.0001013821,0.00009068943],"genre_scores_gemma":[0.008861199,0.9723222,0.0009407987,0.009891815,0.001531197,0.001148904,0.001230763,0.0004105624,0.003662597],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9290587,"threshold_uncertainty_score":0.9997345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06072449683514419,"score_gpt":0.365478809781609,"score_spread":0.3047543129464648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}