{"id":"W2028088201","doi":"10.1016/j.ejpb.2006.10.018","title":"Extended release of high pI proteins from alginate microspheres via a novel encapsulation technique","year":2006,"lang":"en","type":"article","venue":"European Journal of Pharmaceutics and Biopharmaceutics","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":109,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Lysozyme; Isoelectric point; Chemistry; Chymotrypsin; Chromatography; Controlled release; Microsphere; Bovine serum albumin; Drug delivery; Biochemistry; Enzyme; Biophysics; Trypsin; Chemical engineering; Nanotechnology; Materials science; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002261648,0.0005740571,0.0007721382,0.00031527,0.0002585156,0.00005523859,0.0006280972,0.0002277022,0.0002796652],"category_scores_gemma":[0.00008101642,0.0005327658,0.0002649842,0.0004614135,0.0005477077,0.0003624615,0.0002371672,0.001549834,0.0000287653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001247203,"about_ca_system_score_gemma":0.0001218718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006744542,"about_ca_topic_score_gemma":0.000002889359,"domain_scores_codex":[0.9952527,0.001182238,0.001942104,0.0004678143,0.0005294104,0.0006257265],"domain_scores_gemma":[0.9961171,0.0003390678,0.002009759,0.0003145286,0.0007408985,0.0004787139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001095928,0.0008562146,0.001410524,0.0001662307,0.0003533135,0.0004027348,0.0002440135,0.002570904,0.9616295,0.0003068425,0.0004087231,0.03055508],"study_design_scores_gemma":[0.006522535,0.0003461149,0.002880769,0.0001519899,0.0007055875,0.000446469,0.00009896948,0.008273885,0.8796912,0.0006303223,0.09969484,0.000557306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8954369,0.008530904,0.09102201,0.0004713234,0.0018331,0.001186502,0.0005072526,0.00009714387,0.0009148914],"genre_scores_gemma":[0.9798291,0.001498783,0.01677908,0.0005127731,0.0009822568,0.00001004994,0.00004068432,0.0001133112,0.0002339459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09928612,"threshold_uncertainty_score":0.9997124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05181485070297838,"score_gpt":0.359070246959935,"score_spread":0.3072553962569566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}