{"id":"W2028103003","doi":"10.1046/j.1462-5822.2001.00135.x","title":"Phenotypic changes associated with deletion and overexpression of a stage-regulated gene family in Leishmania","year":2001,"lang":"en","type":"article","venue":"Cellular Microbiology","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Wellcome Trust; McMaster University","keywords":"Biology; Gene; Locus (genetics); Null allele; Mutant; Virulence; Genetics; Leishmania major; Phenotype; Gene expression; Cell biology; Lipophosphoglycan; Molecular biology; Leishmania; Leishmania donovani; Parasite hosting; Leishmaniasis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002772158,0.0001678904,0.0004683084,0.0002188924,0.00004801824,0.000005602643,0.00007296762,0.0001859782,0.00005547326],"category_scores_gemma":[0.0001051855,0.0001291353,0.00002887973,0.000284474,0.0002683653,0.00003394378,0.00009470621,0.0001970786,0.00000504921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009392502,"about_ca_system_score_gemma":0.00004802863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001470648,"about_ca_topic_score_gemma":0.0002556111,"domain_scores_codex":[0.9988284,0.0001671909,0.0002327723,0.0003273026,0.00008465291,0.0003597127],"domain_scores_gemma":[0.9993646,0.00007582036,0.0001305404,0.0002110208,0.0001568949,0.00006109526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004619023,0.0001548437,0.04660685,0.00005249454,0.00009581195,0.00008298209,0.0002132541,0.000005188737,0.9515191,0.00001840676,0.0001805845,0.0006086054],"study_design_scores_gemma":[0.005472112,0.001401918,0.3805095,0.0005662894,0.00006489516,0.0000937275,0.0003570699,0.0001545834,0.6081592,0.00002859191,0.002942035,0.000250079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955345,0.003246805,0.00007364417,0.0003587315,0.00002500103,0.00044683,0.00002120686,0.00003065458,0.0002626753],"genre_scores_gemma":[0.9979452,0.0006225872,0.0001975325,0.0001108577,0.00002570963,0.00001628183,0.0001994592,0.0000231963,0.0008591366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3433599,"threshold_uncertainty_score":0.5265983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02218620968936082,"score_gpt":0.2510385962659137,"score_spread":0.2288523865765529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}