{"id":"W2028126801","doi":"10.1016/j.ahj.2010.10.022","title":"A randomized, partially blinded, multicenter, active-controlled, dose-ranging study assessing the safety, efficacy, and pharmacodynamics of the REG1 anticoagulation system in patients with acute coronary syndromes: Design and rationale of the RADAR Phase IIb trial","year":2011,"lang":"en","type":"article","venue":"American Heart Journal","topic":"Acute Myocardial Infarction Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hamilton General Hospital","funders":"","keywords":"Medicine; Pharmacodynamics; Anticoagulant; Acute coronary syndrome; Heparin; Percutaneous coronary intervention; Randomized controlled trial; Dose-ranging study; Factor IXa; Cardiac catheterization; Acenocoumarol; Internal medicine; Warfarin; Placebo; Myocardial infarction; Pharmacokinetics; Atrial fibrillation; Factor X","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002481703,0.0001600451,0.0008751502,0.0001399987,0.0003122117,0.00003713205,0.0001339573,0.00002924316,0.000007866903],"category_scores_gemma":[0.0002766153,0.00007289954,0.0001535825,0.0003594468,0.0006832384,0.0001875409,0.00008000492,0.0004306419,1.624593e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009529969,"about_ca_system_score_gemma":0.0003041899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001091285,"about_ca_topic_score_gemma":0.000003093634,"domain_scores_codex":[0.9956891,0.002484571,0.0007233155,0.0001745361,0.0007211139,0.0002073508],"domain_scores_gemma":[0.9976162,0.001090182,0.0006994235,0.0002299711,0.000278437,0.00008576046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9134516,0.001325656,0.07647031,0.00002033526,0.001594627,0.00001786064,0.00243843,0.0002374844,0.0008086019,0.000006044626,0.00001314802,0.003615966],"study_design_scores_gemma":[0.6569632,0.001345801,0.3264578,0.0001732395,0.000918217,0.0001821036,0.002184342,0.01160056,0.00009924686,0.000002768836,0.000004284766,0.00006842145],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990621,0.00005506413,0.002027354,0.0005519659,0.0001550798,0.006561502,0.000008625372,0.000006236726,0.0000132086],"genre_scores_gemma":[0.998737,0.00005162504,0.0009673949,0.0001255177,0.00004686062,0.00004618342,0.000001308104,0.00001854213,0.000005580383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2564884,"threshold_uncertainty_score":0.2972757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05382176286411853,"score_gpt":0.3630253112405398,"score_spread":0.3092035483764213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}