{"id":"W2028126801","doi":"10.1016/j.ahj.2010.10.022","title":"A randomized, partially blinded, multicenter, active-controlled, dose-ranging study assessing the safety, efficacy, and pharmacodynamics of the REG1 anticoagulation system in patients with acute coronary syndromes: Design and rationale of the RADAR Phase IIb trial","year":2011,"lang":"en","type":"article","venue":"American Heart Journal","topic":"Acute Myocardial Infarction Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hamilton General Hospital","funders":"","keywords":"Medicine; Pharmacodynamics; Anticoagulant; Acute coronary syndrome; Heparin; Percutaneous coronary intervention; Randomized controlled trial; Dose-ranging study; Factor IXa; Cardiac catheterization; Acenocoumarol; Internal medicine; Warfarin; Placebo; Myocardial infarction; Pharmacokinetics; Atrial fibrillation; Factor X","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006364312,0.002780696,0.004179484,0.0005159542,0.0006059262,0.00120864,0.001218996,0.002227695,0.003753561],"category_scores_gemma":[0.005660096,0.0008619484,0.001423259,0.0004683725,0.00204997,0.001284756,0.0005462416,0.004088763,0.001374736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004505487,"about_ca_system_score_gemma":0.001175378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003415195,"about_ca_topic_score_gemma":0.0006458058,"domain_scores_codex":[0.9969,0.002157636,0.0001467805,0.0003844973,0.0002002803,0.0002109089],"domain_scores_gemma":[0.9973265,0.0009438529,0.0006348052,0.0004217812,0.0001560327,0.0005171532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9767718,0.005766131,0.0009699618,0.000374201,0.0007317935,0.00003256506,0.00008193846,0.0004240144,0.003400371,0.0004376975,0.0008599538,0.01014957],"study_design_scores_gemma":[0.9689903,0.02831887,0.0009602896,0.00001556697,0.0003779566,0.00003671322,0.0000113505,0.000244316,0.0002928989,0.0001992344,0.0005385922,0.00001387733],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9749994,0.003380154,0.002694231,0.001236013,0.0004861082,0.01060222,0.001685349,0.0002316476,0.004684895],"genre_scores_gemma":[0.9545736,0.002913515,0.01206003,0.005025926,0.001397417,0.01607308,0.003473108,0.00009862574,0.004384752],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.006364312,"threshold_uncertainty_score":0.03365815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05382176286411853,"score_gpt":0.3630253112405398,"score_spread":0.3092035483764213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}