{"id":"W2028134112","doi":"10.1074/jbc.m113.482109","title":"tBid Undergoes Multiple Conformational Changes at the Membrane Required for Bax Activation","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; University of Ottawa","keywords":"Cell biology; Membrane; Cytoplasm; Bacterial outer membrane; Mitochondrion; Chemistry; Biophysics; Apoptosis; Conformational change; Cell; Inner mitochondrial membrane; Programmed cell death; Cell membrane; Biology; Biochemistry; Gene; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001962724,0.00009438213,0.0001130101,0.000008686526,0.0001077202,0.00002153557,0.0001293735,0.0001885874,0.0002355643],"category_scores_gemma":[0.0002220331,0.00005109239,0.000110481,0.00002567069,0.0000646769,0.000006338739,0.00005068018,0.00006435783,0.000003360968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002482119,"about_ca_system_score_gemma":0.00002672724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002138038,"about_ca_topic_score_gemma":0.000001561334,"domain_scores_codex":[0.9994173,0.00001859432,0.0002312916,0.0001023472,0.0001043792,0.0001260703],"domain_scores_gemma":[0.9992808,0.00007477842,0.0002874065,0.0001022544,0.0002028841,0.00005194751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001117865,0.00002314252,0.00009721499,0.00001771724,0.00003137697,1.563917e-7,0.000008897741,0.00008700066,0.9954154,0.00002154811,0.002277559,0.001908238],"study_design_scores_gemma":[0.0005373395,0.0001656893,0.001024545,0.00001098623,0.00000831876,0.00003178192,0.0000863776,0.0003165645,0.9649435,0.0003035964,0.03248998,0.00008126372],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950143,0.0002298155,0.002495176,0.001432373,0.00009395934,0.0001755238,0.00001146428,0.000004194825,0.0005432264],"genre_scores_gemma":[0.9966685,0.0001751499,0.0005750426,0.0002426438,0.0005762673,0.00001972239,0.0001730598,0.000005938385,0.001563698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03047181,"threshold_uncertainty_score":0.2579264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0260842444036083,"score_gpt":0.2439350030777863,"score_spread":0.217850758674178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}