{"id":"W2028156288","doi":"10.1371/journal.pgen.1004758","title":"Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation","year":2014,"lang":"en","type":"review","venue":"PLoS Genetics","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, San Diego; National Institutes of Health; IXICO; Centre hospitalier régional universitaire de Lille; National Cancer Institute; Servier; Genentech; Erasmus Medisch Centrum; Bundesministerium für Bildung und Forschung; Hjartavernd; Northern California Institute for Research and Education; Institute of Clinical and Translational Sciences; Pfizer; Biogen; BioClinica; Medpace; F. Hoffmann-La Roche; Institut National de la Santé et de la Recherche Médicale; University of Southern California; Brigham Young University; Wellcome Trust; Synarc; Eisai; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; Bristol-Myers Squibb; U.S. Department of Defense; Eli Lilly and Company; BrightFocus Foundation; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; Alzheimer's Association; Foundation for the National Institutes of Health; Alzheimer's Disease Neuroimaging Initiative; National Center for Advancing Translational Sciences; Medical Research Council; Meso Scale Diagnostics","keywords":"Single-nucleotide polymorphism; Genome-wide association study; Biology; Alzheimer's disease; Genetic association; Amyloid beta; Genetics; Gene; Medicine; Disease; Internal medicine; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001997912,0.000821506,0.001075608,0.001323287,0.0005980848,0.001068611,0.0005223958,0.0008391365,0.0009649589],"category_scores_gemma":[0.003989299,0.0003240417,0.002741074,0.003189495,0.0003846008,0.0002589503,0.0006761869,0.0008265612,0.0001254863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003913148,"about_ca_system_score_gemma":0.0005489557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01082751,"about_ca_topic_score_gemma":0.01369399,"domain_scores_codex":[0.9981489,0.0006316958,0.000169936,0.0007379116,0.0001639513,0.0001476516],"domain_scores_gemma":[0.9971704,0.001439489,0.0005706442,0.0003651931,0.0002571205,0.0001971829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.002508507,0.00006250721,0.9696148,0.00025176,0.01777883,0.0004820747,0.0000980251,0.0005186111,0.003896852,0.00008573196,0.0003798291,0.004322522],"study_design_scores_gemma":[0.0001915278,0.0002327826,0.9828328,0.00003822538,0.01332031,0.0005120766,0.00009164494,0.001022089,0.0008455326,0.0001442477,0.0007522008,0.00001655529],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9917892,0.005031475,0.0007655697,0.000156581,0.00002995945,0.00001247524,0.001918162,0.00002253606,0.0002740042],"genre_scores_gemma":[0.9970921,0.0009425824,0.0006557158,0.00005440553,0.0000245781,0.00001493307,0.001060877,0.000008015079,0.0001466673],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.01082751,"threshold_uncertainty_score":0.02152896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06606195400357806,"score_gpt":0.3272489669157582,"score_spread":0.2611870129121802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}