{"id":"W2028156288","doi":"10.1371/journal.pgen.1004758","title":"Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation","year":2014,"lang":"en","type":"review","venue":"PLoS Genetics","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, San Diego; National Institutes of Health; IXICO; Centre hospitalier régional universitaire de Lille; National Cancer Institute; Servier; Genentech; Erasmus Medisch Centrum; Bundesministerium für Bildung und Forschung; Hjartavernd; Northern California Institute for Research and Education; Institute of Clinical and Translational Sciences; Pfizer; Biogen; BioClinica; Medpace; F. Hoffmann-La Roche; Institut National de la Santé et de la Recherche Médicale; University of Southern California; Brigham Young University; Wellcome Trust; Synarc; Eisai; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; Bristol-Myers Squibb; U.S. Department of Defense; Eli Lilly and Company; BrightFocus Foundation; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; Alzheimer's Association; Foundation for the National Institutes of Health; Alzheimer's Disease Neuroimaging Initiative; National Center for Advancing Translational Sciences; Medical Research Council; Meso Scale Diagnostics","keywords":"Single-nucleotide polymorphism; Genome-wide association study; Biology; Alzheimer's disease; Genetic association; Amyloid beta; Genetics; Gene; Medicine; Disease; Internal medicine; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004537898,0.0004353632,0.001714546,0.000433425,0.00009396266,0.00004452269,0.0001494125,0.0002046217,0.000009495753],"category_scores_gemma":[0.0005368966,0.0003393087,0.0001267929,0.0005799404,0.00007629679,0.0001011178,0.00008481265,0.0003228174,0.000003996308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003844016,"about_ca_system_score_gemma":0.001845299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006039948,"about_ca_topic_score_gemma":0.0002283584,"domain_scores_codex":[0.9963887,0.0004712733,0.001095938,0.0004992448,0.001139476,0.000405356],"domain_scores_gemma":[0.9967533,0.0002167148,0.001583496,0.000443016,0.0006559276,0.0003475592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005492704,0.009633306,0.7896573,0.05235026,0.04323334,0.0001488999,0.002460834,0.00005851775,0.000117181,0.000005238574,0.000007509256,0.1017784],"study_design_scores_gemma":[0.02082903,0.009892406,0.7684049,0.0610617,0.129348,0.000003495214,0.001145821,0.001300914,0.001683786,0.0002351944,0.003374782,0.002719984],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.196301,0.7922342,0.00001155178,0.00004041984,0.000008488523,0.01092203,0.0004291309,0.00002599941,0.00002708883],"genre_scores_gemma":[0.6222109,0.3750995,0.0003124763,0.000006721244,0.00008524411,0.001602392,0.0005749436,0.00009677144,0.00001104544],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.4259099,"threshold_uncertainty_score":0.9999059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06606195400357806,"score_gpt":0.3272489669157582,"score_spread":0.2611870129121802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}