{"id":"W2028166816","doi":"10.1097/00004714-200112000-00011","title":"Treatment-Resistance to Clozapine in Association With Ultrarapid CYP1A2 Activity and the C → A Polymorphism in Intron 1 of the CYP1A2 Gene: Effect of Grapefruit Juice and Low-Dose Fluvoxamine","year":2001,"lang":"en","type":"article","venue":"Journal of Clinical Psychopharmacology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Clozapine; Fluvoxamine; CYP1A2; Pharmacology; Atypical antipsychotic; Antipsychotic; Metabolite; Cytochrome P450; CYP2D6; Medicine; Pharmacokinetics; Chemistry; Internal medicine; Schizophrenia (object-oriented programming); Fluoxetine; Metabolism; Psychiatry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003170242,0.0005907231,0.0004899468,0.0004895495,0.0005217073,0.0003995091,0.0002231211,0.0009505783,0.002704141],"category_scores_gemma":[0.001705423,0.0002977338,0.0005846563,0.0004257178,0.0003550143,0.0002112524,0.0001456615,0.0008601435,0.0003153374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003329091,"about_ca_system_score_gemma":0.0001892688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00183618,"about_ca_topic_score_gemma":0.002674369,"domain_scores_codex":[0.999603,0.0001340883,0.0000507852,0.00009411539,0.00006060423,0.0000573925],"domain_scores_gemma":[0.9991276,0.0002527453,0.0003231855,0.00007143246,0.00004837536,0.0001768214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008489011,0.001392081,0.8982809,0.00005133462,0.0004533002,0.02285246,0.0003991576,0.0002232807,0.05357616,0.0001797712,0.0004834755,0.01361909],"study_design_scores_gemma":[0.000201606,0.002048964,0.9441221,0.000009696108,0.0002270354,0.04979378,0.0001035528,0.0006950026,0.00217807,0.0000872629,0.0005078213,0.00002514111],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992049,0.000168172,0.00008108028,0.00008587493,0.000006090946,0.000007658272,0.00004040391,0.000008995158,0.0003967198],"genre_scores_gemma":[0.9995446,0.00004988947,0.00008402218,0.00004657765,0.00001177393,0.000003492351,0.00005731558,0.000003911748,0.0001984185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002704141,"threshold_uncertainty_score":0.009046257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0458833678902309,"score_gpt":0.4533985987353348,"score_spread":0.4075152308451039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}