{"id":"W2028169108","doi":"10.1074/jbc.m111.257071","title":"Tumor Suppressor and Aging Biomarker p16INK4a Induces Cellular Senescence without the Associated Inflammatory Secretory Phenotype","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":501,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Cancer Institute; National Institute on Aging","keywords":"Senescence; Biology; Ectopic expression; Cell biology; Cancer research; DNA damage; Phenotype; Secretion; Cyclin; Kinase; Cancer; Immunology; Cell cycle; Cell culture; Genetics; Endocrinology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006874934,0.000215855,0.0004260674,0.00003530182,0.000115979,0.0000231947,0.0002513539,0.0002135149,0.0002838005],"category_scores_gemma":[0.0006501792,0.0001189586,0.0001360934,0.0001327928,0.0004257697,0.00008624065,0.00008776638,0.000602302,0.000004019314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005233596,"about_ca_system_score_gemma":0.0001099059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000879683,"about_ca_topic_score_gemma":5.071641e-7,"domain_scores_codex":[0.9985746,0.0001016271,0.0005145377,0.0002214162,0.0002865785,0.0003012053],"domain_scores_gemma":[0.9986817,0.0001492378,0.0004946802,0.0002101145,0.0002182211,0.0002460489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002560242,0.0001062202,0.120785,0.00006740089,0.00009938015,0.0003080208,0.0004216534,7.048527e-8,0.8770544,0.000002401557,0.0001077949,0.0007916536],"study_design_scores_gemma":[0.000804132,0.0001387592,0.3754826,0.0002452956,0.00009571522,0.0004450584,0.0005644335,0.0000247291,0.6212415,0.00007931179,0.0006913991,0.0001870938],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969035,0.001872075,0.00003040613,0.0002157588,0.0001222581,0.00009337246,0.000005039453,0.00003215158,0.0007254497],"genre_scores_gemma":[0.9988763,0.0001802734,0.0002322029,0.0003125027,0.0002587574,0.000002284875,0.000004676785,0.00001368401,0.0001192559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2558129,"threshold_uncertainty_score":0.4850993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04343302548424222,"score_gpt":0.2520596045399784,"score_spread":0.2086265790557362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}