{"id":"W2028182635","doi":"10.1371/journal.pgen.1002519","title":"Repression of a Potassium Channel by Nuclear Hormone Receptor and TGF-β Signaling Modulates Insulin Signaling in Caenorhabditis elegans","year":2012,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; National Institute on Aging; British Columbia Knowledge Development Fund; National Institutes of Health","keywords":"Biology; Caenorhabditis elegans; Insulin receptor; Signal transduction; Psychological repression; Cell biology; Potassium channel; Nuclear receptor; Insulin; Endocrinology; Genetics; Transcription factor; Insulin resistance; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002449083,0.0002573838,0.0002968142,0.00007897244,0.00008441939,0.00002654578,0.000208941,0.0002908665,0.0000231739],"category_scores_gemma":[0.00007400802,0.0002747347,0.00006157103,0.0001071258,0.0001157567,0.000009937867,0.0001988344,0.0001711943,0.000005865757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001879426,"about_ca_system_score_gemma":0.00002737136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003398291,"about_ca_topic_score_gemma":0.000006168413,"domain_scores_codex":[0.9983655,0.0001021107,0.0004294525,0.0004084694,0.0002237253,0.0004706912],"domain_scores_gemma":[0.9991466,0.00002110349,0.0001804536,0.000373713,0.00009334401,0.0001847436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004954057,0.0002452147,0.00360043,0.00005769219,0.0000465879,8.337495e-7,0.001661738,0.001241872,0.9922137,0.000004502643,0.0005357637,0.0003421393],"study_design_scores_gemma":[0.0006383783,0.0003242402,0.000945956,0.00005201293,0.00004835764,0.00000644972,0.0003217204,0.003180112,0.9929111,0.00005778718,0.001163878,0.0003500024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845019,0.01441164,0.0005062982,0.00008640933,0.0001172791,0.0002359552,0.00007124974,0.00001653342,0.00005275981],"genre_scores_gemma":[0.99409,0.002314855,0.002942879,0.0001253007,0.0002799253,0.00001071844,0.0001095957,0.00007290029,0.00005387895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01209679,"threshold_uncertainty_score":0.9999705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01094184555620238,"score_gpt":0.2081378397884919,"score_spread":0.1971959942322895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}