{"id":"W2028214376","doi":"10.1016/j.jneumeth.2011.04.016","title":"Unified patch clamp protocol for the characterization of Pannexin 1 channels in isolated cells and acute brain slices","year":2011,"lang":"en","type":"article","venue":"Journal of Neuroscience Methods","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"York University","funders":"National Eye Institute","keywords":"Pannexin; Depolarization; Neuroscience; Membrane potential; Ion channel; Voltage clamp; Patch clamp; Biology; Electrophysiology; Gap junction; Biophysics; Cell biology; Connexin; Intracellular; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00133597,0.00008590602,0.0001635524,0.00007279607,0.00004597577,0.00001403891,0.0002414769,0.00008073834,0.00000327882],"category_scores_gemma":[0.0002035924,0.00005367479,0.00005777261,0.0001496615,0.0001337149,0.00001196755,0.00005848929,0.00009256366,3.511803e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002404285,"about_ca_system_score_gemma":0.00005309694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006686707,"about_ca_topic_score_gemma":0.000003370838,"domain_scores_codex":[0.9990006,0.0003022915,0.0003382167,0.0001571888,0.00005900151,0.0001426866],"domain_scores_gemma":[0.9992511,0.0000848193,0.0003863257,0.0001298271,0.0001092115,0.0000387647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003847582,0.00004485772,0.0004185896,0.00001135153,0.000005862722,0.000001823308,0.0002008264,0.000003934501,0.9927306,0.00002305254,0.00001184126,0.006162567],"study_design_scores_gemma":[0.0007262208,0.002004765,0.01897474,0.00001679011,0.0000123929,0.00005197652,0.00005004265,0.001761353,0.9593671,0.0001155088,0.01683499,0.00008410692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.855888,0.00001219592,0.1349763,0.0004475503,0.0003268148,0.008318665,0.0000100668,0.000001854226,0.00001852767],"genre_scores_gemma":[0.9692805,0.0001552362,0.0247049,0.001567492,0.0002426787,0.003698955,0.000002936744,0.00002666699,0.000320671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1133924,"threshold_uncertainty_score":0.2188795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07716024654617806,"score_gpt":0.3885925796182445,"score_spread":0.3114323330720664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}