{"id":"W2028223954","doi":"10.1016/j.vaccine.2010.03.029","title":"Scalable production of influenza virus in HEK-293 cells for efficient vaccine manufacturing","year":2010,"lang":"en","type":"article","venue":"Vaccine","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Research Council Canada; Polytechnique Montréal","funders":"","keywords":"HEK 293 cells; Virology; Virus; Titer; Biology; Influenza vaccine; Cell culture; Influenza A virus; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001546844,0.0001299482,0.0001516957,0.00007952253,0.00005551135,0.000009974817,0.000110055,0.0001150975,0.00005766404],"category_scores_gemma":[0.00007879329,0.0001140782,0.00008027373,0.0000779587,0.000005650161,0.000004021662,0.0000703738,0.0000930368,0.000005359575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007746231,"about_ca_system_score_gemma":0.0000273803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006693634,"about_ca_topic_score_gemma":0.0001673499,"domain_scores_codex":[0.9991279,0.00001678482,0.0002655752,0.000312241,0.00007320325,0.0002042751],"domain_scores_gemma":[0.9994214,0.00000936864,0.0001063673,0.0003371628,0.00007427129,0.00005144411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002931581,0.0001982664,0.002361929,0.0000635493,0.0000139806,4.202566e-7,0.00001609983,0.004685845,0.9869644,0.0000110494,0.004403056,0.0009882174],"study_design_scores_gemma":[0.001067912,0.0002189213,0.008353974,0.00002051417,0.00001169243,0.000003321452,0.000009569963,0.0001674266,0.9733627,0.00006729337,0.01658699,0.000129637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981925,0.0002198315,0.0001565508,0.00006037368,0.000880416,0.0003791668,0.00001808192,0.0000126193,0.00008045995],"genre_scores_gemma":[0.9987335,0.00003861323,0.0003596698,0.0001065771,0.0003536537,0.00005801399,0.00002853233,0.00002027533,0.0003012086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01360169,"threshold_uncertainty_score":0.4651975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007344304412310092,"score_gpt":0.2578446994893022,"score_spread":0.2505003950769921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}