{"id":"W2028223954","doi":"10.1016/j.vaccine.2010.03.029","title":"Scalable production of influenza virus in HEK-293 cells for efficient vaccine manufacturing","year":2010,"lang":"en","type":"article","venue":"Vaccine","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Research Council Canada; Polytechnique Montréal","funders":"","keywords":"HEK 293 cells; Virology; Virus; Titer; Biology; Influenza vaccine; Cell culture; Influenza A virus; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005005152,0.000494553,0.0008028016,0.0003318464,0.000392828,0.0008457498,0.0006287936,0.0004874941,0.001897883],"category_scores_gemma":[0.0003993203,0.0004350713,0.0006384416,0.0005025457,0.0002552124,0.000572084,0.0005111743,0.001514234,0.001949332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005413931,"about_ca_system_score_gemma":0.0003699663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007533467,"about_ca_topic_score_gemma":0.001334161,"domain_scores_codex":[0.9996045,0.00005221759,0.00004718312,0.00006838334,0.0001758367,0.00005182176],"domain_scores_gemma":[0.9998394,0.00005215988,0.00002518777,0.00003949803,0.00002406916,0.00001970953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004303397,0.00003332506,0.00007410134,0.00004928649,0.000006710589,0.00003317368,0.00001622338,0.0003395744,0.9966121,0.0002069207,0.0001898886,0.002395619],"study_design_scores_gemma":[0.00002912714,0.0001244599,0.000536594,0.000009403641,0.00001628315,0.00008227592,0.00001966755,0.003407985,0.9913192,0.0001776991,0.004268887,0.000008328511],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6019264,0.002709888,0.3686361,0.0006322018,0.0004344523,0.001971717,0.009206499,0.002919193,0.01156365],"genre_scores_gemma":[0.6728541,0.002910819,0.298508,0.0001456654,0.00007508426,0.001515394,0.01449069,0.0004198921,0.009080432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001897883,"threshold_uncertainty_score":0.006349027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007344304412310092,"score_gpt":0.2578446994893022,"score_spread":0.2505003950769921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}