{"id":"W2028224002","doi":"10.1093/nar/gks222","title":"CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage","year":2012,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Biology; DNA damage; BMI1; Polycomb-group proteins; SUMO protein; Cell biology; DNA repair; Gene silencing; Epigenetics; DNA; Ubiquitin ligase; Histone; Molecular biology; Genetics; Ubiquitin; Gene; Stem cell; Repressor; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001325056,0.0002902903,0.0002307554,0.0003102249,0.0002539391,0.0003445415,0.000258612,0.0002081717,0.00200189],"category_scores_gemma":[0.0001678274,0.0001697133,0.0002129779,0.0001408006,0.0003172416,0.0002371437,0.0004169637,0.0003772479,0.000588059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005725701,"about_ca_system_score_gemma":0.0002696426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001098333,"about_ca_topic_score_gemma":0.001393817,"domain_scores_codex":[0.9998968,0.00001374033,0.000005627887,0.00002419828,0.00002384945,0.00003581981],"domain_scores_gemma":[0.9998994,0.00001250795,0.00002736937,0.00001101579,0.00001392082,0.00003572483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001465057,0.00001246409,0.0004386648,0.00001811448,0.000002558319,0.0000296975,0.000009141357,0.00006415358,0.9984691,0.0000748997,0.00002555825,0.0007092528],"study_design_scores_gemma":[0.00002433045,0.00007870786,0.02277933,0.000005116734,0.000007533961,0.0001124408,0.00002910827,0.001274091,0.9746646,0.00007549904,0.0009446538,0.000004546896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959112,0.0008876493,0.00149622,0.00006293484,0.00001347405,0.00001573997,0.0001684388,0.00007513246,0.001369344],"genre_scores_gemma":[0.995317,0.0003807867,0.0008810902,0.00001854501,0.000004699318,0.00002321518,0.0002439288,0.00001547058,0.003115198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00200189,"threshold_uncertainty_score":0.006696939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1381166890318264,"score_gpt":0.3725817871860799,"score_spread":0.2344650981542535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}