{"id":"W2028239287","doi":"10.1021/bc0000233","title":"Site Specific 1:1 Opioid:Albumin Conjugate with in Vitro Activity and Long in Vivo Duration","year":2000,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"ConjuChem (Canada)","funders":"","keywords":"Chemistry; In vivo; Pharmacology; Dynorphin; Conjugate; Opioid; In vitro; Nociception; Albumin; Bovine serum albumin; Agonist; Analgesic; Dynorphin A; Receptor; Opioid peptide; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001266412,0.0002134491,0.0002952433,0.00004204168,0.00004235201,0.00002907103,0.00004045671,0.0001332332,0.0005696512],"category_scores_gemma":[0.000007748969,0.0001830074,0.00002996844,0.0001479436,0.00007069941,0.00008811922,0.00001527326,0.0001797815,0.00002561514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000128337,"about_ca_system_score_gemma":0.00004816664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001646598,"about_ca_topic_score_gemma":0.00005427097,"domain_scores_codex":[0.9989412,0.00002092551,0.0002077072,0.0004068496,0.0001470404,0.0002762586],"domain_scores_gemma":[0.9995362,0.00002405191,0.00005617596,0.0002369173,0.00001898406,0.0001277306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001226004,0.0002352797,0.01359927,0.0001306225,0.00001833552,0.000518055,0.0001427916,0.000001113462,0.9778081,0.000002281708,0.00002306226,0.006295043],"study_design_scores_gemma":[0.003953203,0.00006956895,0.03217034,0.0001780034,0.00001951107,0.00009886169,0.00004092497,0.000143636,0.9623069,0.00003022631,0.0008034309,0.0001854321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961483,0.0003171427,0.000009928729,0.0001792606,0.00001317019,0.0003505446,0.00002413661,0.00003316709,0.002924374],"genre_scores_gemma":[0.996794,0.0003376456,0.0003157521,0.00007738011,0.00005590481,0.00004535833,0.00005119377,0.00002224279,0.002300478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01857107,"threshold_uncertainty_score":0.7462825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008490385539327247,"score_gpt":0.2242157551459566,"score_spread":0.2157253696066294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}