{"id":"W2028240691","doi":"10.1097/wnr.0b013e3283179333","title":"Block of purinergic P2X7 receptor is neuroprotective in an animal model of Alzheimer's disease","year":2008,"lang":"en","type":"article","venue":"Neuroreport","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Fondation pour la Recherche sur Alzheimer","keywords":"Neuroprotection; Purinergic receptor; Gliosis; Agonist; Pharmacology; Ionotropic effect; Blood–brain barrier; Receptor; Neuroscience; Medicine; Internal medicine; Endocrinology; Biology; NMDA receptor; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006903855,0.0001457151,0.0002013921,0.00006585204,0.00002766433,0.000002222935,0.0001392581,0.00007110143,0.00001742164],"category_scores_gemma":[0.00005085218,0.000144693,0.0001005176,0.0001195598,0.00009667181,0.000007871205,0.00008419614,0.00009628914,9.613852e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002783463,"about_ca_system_score_gemma":0.0001592198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003543633,"about_ca_topic_score_gemma":9.74041e-7,"domain_scores_codex":[0.9988378,0.00004278514,0.0004022664,0.0003739088,0.0001800248,0.0001632652],"domain_scores_gemma":[0.9991564,0.000004161059,0.0002150102,0.0003995163,0.0001173677,0.0001076084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004112503,0.0002730059,0.0407003,0.00001743936,0.00002756916,0.0001363881,0.0001002592,0.006518391,0.9503715,0.00001256246,0.001363805,0.00006752054],"study_design_scores_gemma":[0.0005559716,0.0007800662,0.0385895,0.00001372387,0.00004388453,0.00008197398,0.00001586068,0.004083139,0.9551857,0.0000639297,0.000347761,0.0002384516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988354,0.0005150028,0.00003566277,0.00005613386,0.00003749344,0.0001686813,0.00002695455,0.000008317265,0.000316328],"genre_scores_gemma":[0.9992927,0.00008087745,0.0002426106,0.0001363774,0.00008457807,0.00001500452,0.0000284632,0.00002708568,0.00009233061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004814229,"threshold_uncertainty_score":0.590041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03553994478021088,"score_gpt":0.2658238038463557,"score_spread":0.2302838590661448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}