{"id":"W2028245933","doi":"10.1016/j.vaccine.2005.06.011","title":"Candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: Developmental chemistry and investigation of immunological responses following immunization of mice and rabbits","year":2005,"lang":"en","type":"article","venue":"Vaccine","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Biological Sciences; Steacie Institute for Molecular Sciences","funders":"Medical Research Council","keywords":"Lipid A; Epitope; Heptose; Glycoconjugate; Lipopolysaccharide; Antigen; Microbiology; Neisseria meningitidis; Antigenicity; Heterologous; Residue (chemistry); Mutant; Chemistry; Biology; Biochemistry; Immunology; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001399459,0.0001092525,0.0002455869,0.00006485394,0.00006344721,0.000004299132,0.00005923864,0.00009200087,0.00008985881],"category_scores_gemma":[0.0002689412,0.00009517806,0.00003371324,0.0001352709,0.00003289089,0.00007340511,0.00007327792,0.00005713231,0.000001098303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002120009,"about_ca_system_score_gemma":0.00009459343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001340259,"about_ca_topic_score_gemma":0.00002440836,"domain_scores_codex":[0.9993151,0.00007516925,0.0003441623,0.0001478281,0.00001580557,0.0001018857],"domain_scores_gemma":[0.9994755,0.0001723695,0.0001576954,0.00008825181,0.00007869222,0.00002747531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007192548,0.00007347341,0.06792891,0.00006455774,0.0000816467,1.917525e-7,0.0002831884,0.000008851176,0.9297799,0.00001487705,0.00002206019,0.001023056],"study_design_scores_gemma":[0.001106545,0.0001254248,0.2192715,0.0001289404,0.00004276436,0.000006132466,0.00008961425,0.000003918225,0.7789485,0.0000117876,0.0001918645,0.00007296768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975738,0.001848191,0.00001993982,0.0002441284,0.00004243963,0.0002217542,0.00003055524,0.00001282598,0.000006380953],"genre_scores_gemma":[0.9991199,0.00009083319,0.0005723519,0.00001827575,0.00001002221,0.00001207048,0.00009162601,0.000006600891,0.0000782765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1513426,"threshold_uncertainty_score":0.3881249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009716160945571817,"score_gpt":0.2354155138622512,"score_spread":0.2256993529166794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}