{"id":"W2028245933","doi":"10.1016/j.vaccine.2005.06.011","title":"Candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: Developmental chemistry and investigation of immunological responses following immunization of mice and rabbits","year":2005,"lang":"en","type":"article","venue":"Vaccine","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Biological Sciences; Steacie Institute for Molecular Sciences","funders":"Medical Research Council","keywords":"Lipid A; Epitope; Heptose; Glycoconjugate; Lipopolysaccharide; Antigen; Microbiology; Neisseria meningitidis; Antigenicity; Heterologous; Residue (chemistry); Mutant; Chemistry; Biology; Biochemistry; Immunology; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003002875,0.0003057212,0.0001483099,0.0002751047,0.0001459582,0.0002475532,0.0002660017,0.0003018378,0.0007004961],"category_scores_gemma":[0.0003338763,0.0001541918,0.0002423465,0.0001670217,0.0002422795,0.0002455691,0.0001264968,0.0005164497,0.0001886753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002739099,"about_ca_system_score_gemma":0.0002733349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007731675,"about_ca_topic_score_gemma":0.0007533992,"domain_scores_codex":[0.9998994,0.00002403441,0.000005238742,0.00001096493,0.00001898068,0.00004140586],"domain_scores_gemma":[0.9998181,0.00003414186,0.00004327562,0.00002628068,0.00003076578,0.000047421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004172903,0.00006007458,0.0001695622,0.00001372358,0.000004381246,0.00003800668,0.00001846388,0.0001040735,0.9974896,0.0002804773,0.00001885299,0.001385558],"study_design_scores_gemma":[0.00002149441,0.0006579406,0.001506334,0.000002321073,0.000008513141,0.00005899477,0.00001081342,0.0002677254,0.9967639,0.00006201064,0.000637341,0.000002472495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995702,0.0004972891,0.002263563,0.00006685718,0.00001932791,0.00003454551,0.0001023779,0.00002104963,0.00129291],"genre_scores_gemma":[0.9957296,0.0004506106,0.001178249,0.00005419514,0.00001051795,0.0000196168,0.0002163058,0.00001471884,0.002325991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007731675,"threshold_uncertainty_score":0.002343416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009716160945571817,"score_gpt":0.2354155138622512,"score_spread":0.2256993529166794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}