{"id":"W2028267102","doi":"10.1038/ncb1441","title":"A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K–Akt signalling","year":2006,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":353,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"RIKEN Brain Science Institute; Fondazione Italiana per la Ricerca sul Cancro","keywords":"Parkin; Ubiquitin ligase; Ubiquitin; Cell biology; Endocytosis; Protein kinase B; Biology; Proteasome; Signal transduction; Internalization; Receptor; Parkinson's disease; Biochemistry; Medicine; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002387639,0.0001785175,0.0001506062,0.00005190439,0.00008290923,0.00002380369,0.0001430883,0.0005291541,0.00001631765],"category_scores_gemma":[0.00002124647,0.0001167863,0.00003704635,0.000128946,0.0001098261,0.000004059285,0.00005350823,0.0004633782,0.000003458211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001536,"about_ca_system_score_gemma":0.00003226993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005574417,"about_ca_topic_score_gemma":0.0002160057,"domain_scores_codex":[0.9989479,0.0001529943,0.0001716343,0.0004092773,0.0000481919,0.0002699906],"domain_scores_gemma":[0.9995925,0.00003453421,0.0001146254,0.0001753707,0.00005143091,0.00003150323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002272335,0.00003977865,0.0008185002,0.00001688963,0.00001337603,0.000001831991,0.00004380596,0.00005475332,0.995937,0.0001424123,0.0003694587,0.002334906],"study_design_scores_gemma":[0.0005105226,0.0003489297,0.0005038651,0.00002951373,0.000008270476,0.00001533972,0.00006901952,0.00006876689,0.93612,0.0001241647,0.06202167,0.0001799894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943999,0.003193652,0.0001429257,0.0006406294,0.00007057616,0.0004697725,0.00001077315,0.00002077791,0.00105097],"genre_scores_gemma":[0.9984735,0.00004359393,0.0004674663,0.000204425,0.0002890559,0.00008097503,0.0002206907,0.00002007271,0.000200221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06165221,"threshold_uncertainty_score":0.4762409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004926001021019207,"score_gpt":0.2199784419581063,"score_spread":0.2150524409370871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}