{"id":"W2028296987","doi":"10.1021/jm020078l","title":"Probing Opioid Receptor Interactions with Azacycloalkane Amino Acids. Synthesis of a Potent and Selective ORL1 Antagonist","year":2002,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Nociceptin receptor; Stereochemistry; Opioid peptide; Receptor; Opioid receptor; Antagonist; Peptide; Amino acid; Opioid; Peptide synthesis; Chemical synthesis; NOP; Selectivity; Combinatorial chemistry; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008163738,0.0001265471,0.0002973797,0.0000409649,0.00007974577,0.00001434446,0.0001535481,0.00003305662,0.0001201988],"category_scores_gemma":[0.0004103129,0.00008664811,0.00005694601,0.0001402214,0.0002439124,0.0001233784,0.00003507017,0.0004008735,0.000002464098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004010951,"about_ca_system_score_gemma":0.0000355684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003726347,"about_ca_topic_score_gemma":3.259766e-7,"domain_scores_codex":[0.9990342,0.00003738857,0.0003341541,0.0001773887,0.0002538374,0.0001629833],"domain_scores_gemma":[0.9989851,0.0002415573,0.0004550781,0.00008810576,0.0001054068,0.0001247449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000261448,0.0001328674,0.0002003293,0.0001031148,0.00001822542,0.0001009432,0.000201671,0.000004737298,0.9946356,0.000004469744,0.0005168924,0.003819644],"study_design_scores_gemma":[0.0003883113,0.0005241397,0.0004840152,0.0003978531,0.00005145618,0.00254212,0.0003292027,0.0000501032,0.9934403,0.00001874141,0.001686355,0.00008744473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959985,0.0001035465,0.00001035,0.00037981,0.00006968753,0.00004837504,0.00000599536,0.000007140541,0.003376567],"genre_scores_gemma":[0.9988475,0.0003302407,0.0001775591,0.0001282644,0.0002419191,0.000002184805,1.682599e-7,0.00001232044,0.0002598799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003732199,"threshold_uncertainty_score":0.3533407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01787068333988392,"score_gpt":0.2366504373077539,"score_spread":0.21877975396787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}