{"id":"W2028296987","doi":"10.1021/jm020078l","title":"Probing Opioid Receptor Interactions with Azacycloalkane Amino Acids. Synthesis of a Potent and Selective ORL1 Antagonist","year":2002,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Nociceptin receptor; Stereochemistry; Opioid peptide; Receptor; Opioid receptor; Antagonist; Peptide; Amino acid; Opioid; Peptide synthesis; Chemical synthesis; NOP; Selectivity; Combinatorial chemistry; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001042923,0.0002854883,0.0002591731,0.00008138977,0.000106929,0.0001494872,0.0001868905,0.0002371539,0.0008402867],"category_scores_gemma":[0.0001420826,0.0001353462,0.0001230832,0.00006855819,0.000137584,0.000166016,0.0001061429,0.0003563685,0.0003411488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002184465,"about_ca_system_score_gemma":0.0001281224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003687283,"about_ca_topic_score_gemma":0.0006707295,"domain_scores_codex":[0.9999139,0.00002084608,0.000003842094,0.00001461093,0.00001871889,0.00002803877],"domain_scores_gemma":[0.9999301,0.00002116342,0.00002074492,0.000004476198,0.000007576487,0.00001583734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008609783,0.00001226196,0.00007094321,0.0000283579,0.00000415227,0.00004295728,0.00001340144,0.000141339,0.998762,0.00004769479,0.000009354744,0.0007813941],"study_design_scores_gemma":[0.00002085484,0.0007161942,0.0009158437,0.000003301926,0.0000149374,0.0001968117,0.00001361633,0.0004840885,0.9961008,0.00002464793,0.001503174,0.000005716463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936539,0.002258825,0.002193258,0.00006166031,0.00001301956,0.00003442258,0.00009946777,0.00002162083,0.001663844],"genre_scores_gemma":[0.9942554,0.001636821,0.002666675,0.00005807741,0.00001129791,0.00003536539,0.0001534782,0.000009341476,0.001173636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008402867,"threshold_uncertainty_score":0.002811015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01787068333988392,"score_gpt":0.2366504373077539,"score_spread":0.21877975396787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}